Disruption of the meprin α and β genes in mice alters homeostasis of monocytes and natural killer cells

Qi Sun*, Hong Jian Jin, Judith S. Bond

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    24 Scopus citations

    Abstract

    Meprin metalloproteases are implicated in inflammatory bowel disease, which involves dysfunction of immune cells. However, the roles of meprins in the immune and hematological system remain uncharacterized. In this report, we demonstrate that meprins were expressed in the hematological system, and meprin α/β null (α-/--/-) mice had decreased prevalence of resident monocytes and natural killer (NK) cells in blood, with a concomitant accumulation of inflammatory monocytes and NK cells in bone marrow. In contrast, T and B lymphocytes were not affected by meprin deficiency. In response to acute inflammation induced by intraperitoneal injection of thioglycollate, meprin-deficient mice exhibited higher body temperature than wild-type mice, which was correlated with retention of inflammatory monocytes, but persistent low prevalence of NK cells in blood. These results indicate that meprin metalloproteases play important roles in the homeostasis of monocytes and NK cells, and possibly are involved in egress of these two type cells from bone marrow and homing to the periphery. Our findings are the first report to demonstrate that metalloproteases affect homeostasis of leukocytes, which have important implications for understanding physiology of and pathogenesis in the hematological system.

    Original languageEnglish (US)
    Pages (from-to)346-356
    Number of pages11
    JournalExperimental Hematology
    Volume37
    Issue number3
    DOIs
    StatePublished - Mar 2009

    ASJC Scopus subject areas

    • Molecular Biology
    • Hematology
    • Genetics
    • Cell Biology
    • Cancer Research

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