Abstract
An immunosuppressed recipient of a renal allograft developed bilateral necrotizing retinitis. Disseminated herpes simplex infection was documented by clinical findings and serologic and viral culture studies. Cultures and serologic tests for cytomegalovirus were negative. The evidence strongly favored the diagnosis of herpes simplex retinitis. Tapering of immunosuppressive drugs and administration of adenine arabinoside appeared to halt temporarily the progression of the disease in one eye and resulted in healing of the retinitis in the other eye. Subsequent progression of the more severely involved right eye resulted in an exudative retinal detachment and loss of vision prior to the patient's death from meningoencephalitis. Herpes simplex retinitis must be considered in the differential diagnosis of necrotizing retinitis in an immunosuppressed patient.
Original language | English (US) |
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Pages (from-to) | 175-178 |
Number of pages | 4 |
Journal | Ophthalmology |
Volume | 90 |
Issue number | 2 |
DOIs | |
State | Published - 1983 |
Funding
Supported in part by grants EY 02214 and EY 1792 from the National Eye Institute, National Institutes of Health. Bethesda, Maryland.
Keywords
- adenine arabinoside
- cytomegalovirus
- herpes simplex
- renal transplant
- retinitis
ASJC Scopus subject areas
- Ophthalmology