Disseminated intravascular coagulation associated with granulocyte colony-stimulating factor therapy in a child with human immunodeficiency virus infection

Brigitta U. Mueller, Richard Burt, Leslie Gulick, Freda Jacobsen, Philip A. Pizzo, McDonald Horne

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

We report a case of disseminated intravascular coagulopathy, apparently caused by exposure to granulocyte colony-stimulating factor (G-CSF). The medical records of patients treated for more than 30 consecutive days with subcutaneously administered G-CSF were reviewed for the occurrence of thrombocytopenia or coagulation abnormalities. New-onset thrombocytopenia with a platelet count less than 100 × 10 9 cells/L (<100,000 cells/mm 3 ) developed in 9 of 23 patients (39%) after a median of 11 weeks of treatment with G-CSF at dosages between 1 and 10 μg/kg per day. (J P EDIATR 1995;126:749-52).

Original languageEnglish (US)
Pages (from-to)749-752
Number of pages4
JournalThe Journal of Pediatrics
Volume126
Issue number5
DOIs
StatePublished - Jan 1 1995

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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