Dissolvable films of silk fibroin for ultrathin conformal bio-integrated electronics

Dae Hyeong Kim; Jonathan Viventi; Jason J. Amsden; Jianliang Xiao; Leif Vigeland; Yun Soung Kim; Justin A. Blanco; Bruce Panilaitis; Eric S. Frechette; Diego Contreras; David L. Kaplan; Fiorenzo G. Omenetto; Yonggang Huang; Keh Chih Hwang; Mitchell R. Zakin; Brian Litt; John A. Rogers

doi:10.1038/nmat2745

Dissolvable films of silk fibroin for ultrathin conformal bio-integrated electronics

Dae Hyeong Kim, Jonathan Viventi, Jason J. Amsden, Jianliang Xiao, Leif Vigeland, Yun Soung Kim, Justin A. Blanco, Bruce Panilaitis, Eric S. Frechette, Diego Contreras, David L. Kaplan, Fiorenzo G. Omenetto, Yonggang Huang, Keh Chih Hwang, Mitchell R. Zakin, Brian Litt^*, John A. Rogers

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

1447 Scopus citations

Abstract

Electronics that are capable of intimate, non-invasive integration with the soft, curvilinear surfaces of biological tissues offer important opportunities for diagnosing and treating disease and for improving brain/machine interfaces. This article describes a material strategy for a type of bio-interfaced system that relies on ultrathin electronics supported by bioresorbable substrates of silk fibroin. Mounting such devices on tissue and then allowing the silk to dissolve and resorb initiates a spontaneous, conformal wrapping process driven by capillary forces at the biotic/abiotic interface. Specialized mesh designs and ultrathin forms for the electronics ensure minimal stresses on the tissue and highly conformal coverage, even for complex curvilinear surfaces, as confirmed by experimental and theoretical studies. In vivo, neural mapping experiments on feline animal models illustrate one mode of use for this class of technology. These concepts provide new capabilities for implantable and surgicalÂ devices.

Original language	English (US)
Pages (from-to)	511-517
Number of pages	7
Journal	Nature materials
Volume	9
Issue number	6
DOIs	https://doi.org/10.1038/nmat2745
State	Published - Apr 2010

Funding

We thank T. Banks and J. A. N. T. Soares for help using facilities at the Frederick Seitz Materials Research Laboratory. This material is based on work supported by a National Security Science and Engineering Faculty Fellowship and the US Department of Energy, Division of Materials Sciences under Award No. DEFG02-91ER45439, through the Frederick Seitz MRL and Center for Microanalysis of Materials at the University of Illinois at Urbana-Champaign. The aspects of the work relating to silk are supported by the US Army Research Laboratory and the US Army Research Office under contract number W911 NF-07-1-0618 and by the DARPA-DSO and the NIH P41 Tissue Engineering Resource Center (P41 EB002520). Work at the University of Pennsylvania is supported by the National Institutes of Health Grants (NINDS RO1-NS041811-04, R01 NS 48598-04), and the Klingenstein Foundation. J.A.R. is supported by a National Science Security and Engineering Faculty Fellowship.

ASJC Scopus subject areas

General Chemistry
Condensed Matter Physics
Mechanics of Materials
Mechanical Engineering
General Materials Science

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10.1038/nmat2745

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Kim, D. H., Viventi, J., Amsden, J. J., Xiao, J., Vigeland, L., Kim, Y. S., Blanco, J. A., Panilaitis, B., Frechette, E. S., Contreras, D., Kaplan, D. L., Omenetto, F. G., Huang, Y., Hwang, K. C., Zakin, M. R., Litt, B., & Rogers, J. A. (2010). Dissolvable films of silk fibroin for ultrathin conformal bio-integrated electronics. Nature materials, 9(6), 511-517. https://doi.org/10.1038/nmat2745

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title = "Dissolvable films of silk fibroin for ultrathin conformal bio-integrated electronics",

abstract = "Electronics that are capable of intimate, non-invasive integration with the soft, curvilinear surfaces of biological tissues offer important opportunities for diagnosing and treating disease and for improving brain/machine interfaces. This article describes a material strategy for a type of bio-interfaced system that relies on ultrathin electronics supported by bioresorbable substrates of silk fibroin. Mounting such devices on tissue and then allowing the silk to dissolve and resorb initiates a spontaneous, conformal wrapping process driven by capillary forces at the biotic/abiotic interface. Specialized mesh designs and ultrathin forms for the electronics ensure minimal stresses on the tissue and highly conformal coverage, even for complex curvilinear surfaces, as confirmed by experimental and theoretical studies. In vivo, neural mapping experiments on feline animal models illustrate one mode of use for this class of technology. These concepts provide new capabilities for implantable and surgical{\^A} devices.",

author = "Kim, {Dae Hyeong} and Jonathan Viventi and Amsden, {Jason J.} and Jianliang Xiao and Leif Vigeland and Kim, {Yun Soung} and Blanco, {Justin A.} and Bruce Panilaitis and Frechette, {Eric S.} and Diego Contreras and Kaplan, {David L.} and Omenetto, {Fiorenzo G.} and Yonggang Huang and Hwang, {Keh Chih} and Zakin, {Mitchell R.} and Brian Litt and Rogers, {John A.}",

note = "Funding Information: We thank T. Banks and J. A. N. T. Soares for help using facilities at the Frederick Seitz Materials Research Laboratory. This material is based on work supported by a National Security Science and Engineering Faculty Fellowship and the US Department of Energy, Division of Materials Sciences under Award No. DEFG02-91ER45439, through the Frederick Seitz MRL and Center for Microanalysis of Materials at the University of Illinois at Urbana-Champaign. The aspects of the work relating to silk are supported by the US Army Research Laboratory and the US Army Research Office under contract number W911 NF-07-1-0618 and by the DARPA-DSO and the NIH P41 Tissue Engineering Resource Center (P41 EB002520). Work at the University of Pennsylvania is supported by the National Institutes of Health Grants (NINDS RO1-NS041811-04, R01 NS 48598-04), and the Klingenstein Foundation. J.A.R. is supported by a National Science Security and Engineering Faculty Fellowship.",

year = "2010",

month = apr,

doi = "10.1038/nmat2745",

language = "English (US)",

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pages = "511--517",

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Kim, DH, Viventi, J, Amsden, JJ, Xiao, J, Vigeland, L, Kim, YS, Blanco, JA, Panilaitis, B, Frechette, ES, Contreras, D, Kaplan, DL, Omenetto, FG, Huang, Y, Hwang, KC, Zakin, MR, Litt, B & Rogers, JA 2010, 'Dissolvable films of silk fibroin for ultrathin conformal bio-integrated electronics', Nature materials, vol. 9, no. 6, pp. 511-517. https://doi.org/10.1038/nmat2745

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T1 - Dissolvable films of silk fibroin for ultrathin conformal bio-integrated electronics

AU - Kim, Dae Hyeong

AU - Viventi, Jonathan

AU - Amsden, Jason J.

AU - Xiao, Jianliang

AU - Vigeland, Leif

AU - Kim, Yun Soung

AU - Blanco, Justin A.

AU - Panilaitis, Bruce

AU - Frechette, Eric S.

AU - Contreras, Diego

AU - Kaplan, David L.

AU - Omenetto, Fiorenzo G.

AU - Huang, Yonggang

AU - Hwang, Keh Chih

AU - Zakin, Mitchell R.

AU - Litt, Brian

AU - Rogers, John A.

N1 - Funding Information: We thank T. Banks and J. A. N. T. Soares for help using facilities at the Frederick Seitz Materials Research Laboratory. This material is based on work supported by a National Security Science and Engineering Faculty Fellowship and the US Department of Energy, Division of Materials Sciences under Award No. DEFG02-91ER45439, through the Frederick Seitz MRL and Center for Microanalysis of Materials at the University of Illinois at Urbana-Champaign. The aspects of the work relating to silk are supported by the US Army Research Laboratory and the US Army Research Office under contract number W911 NF-07-1-0618 and by the DARPA-DSO and the NIH P41 Tissue Engineering Resource Center (P41 EB002520). Work at the University of Pennsylvania is supported by the National Institutes of Health Grants (NINDS RO1-NS041811-04, R01 NS 48598-04), and the Klingenstein Foundation. J.A.R. is supported by a National Science Security and Engineering Faculty Fellowship.

PY - 2010/4

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N2 - Electronics that are capable of intimate, non-invasive integration with the soft, curvilinear surfaces of biological tissues offer important opportunities for diagnosing and treating disease and for improving brain/machine interfaces. This article describes a material strategy for a type of bio-interfaced system that relies on ultrathin electronics supported by bioresorbable substrates of silk fibroin. Mounting such devices on tissue and then allowing the silk to dissolve and resorb initiates a spontaneous, conformal wrapping process driven by capillary forces at the biotic/abiotic interface. Specialized mesh designs and ultrathin forms for the electronics ensure minimal stresses on the tissue and highly conformal coverage, even for complex curvilinear surfaces, as confirmed by experimental and theoretical studies. In vivo, neural mapping experiments on feline animal models illustrate one mode of use for this class of technology. These concepts provide new capabilities for implantable and surgicalÂ devices.

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Dissolvable films of silk fibroin for ultrathin conformal bio-integrated electronics

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