Dissolvable films of silk fibroin for ultrathin conformal bio-integrated electronics

Dae Hyeong Kim, Jonathan Viventi, Jason J. Amsden, Jianliang Xiao, Leif Vigeland, Yun Soung Kim, Justin A. Blanco, Bruce Panilaitis, Eric S. Frechette, Diego Contreras, David L. Kaplan, Fiorenzo G. Omenetto, Yonggang Huang, Keh Chih Hwang, Mitchell R. Zakin, Brian Litt*, John A. Rogers

*Corresponding author for this work

Research output: Contribution to journalArticle

822 Citations (Scopus)

Abstract

Electronics that are capable of intimate, non-invasive integration with the soft, curvilinear surfaces of biological tissues offer important opportunities for diagnosing and treating disease and for improving brain/machine interfaces. This article describes a material strategy for a type of bio-interfaced system that relies on ultrathin electronics supported by bioresorbable substrates of silk fibroin. Mounting such devices on tissue and then allowing the silk to dissolve and resorb initiates a spontaneous, conformal wrapping process driven by capillary forces at the biotic/abiotic interface. Specialized mesh designs and ultrathin forms for the electronics ensure minimal stresses on the tissue and highly conformal coverage, even for complex curvilinear surfaces, as confirmed by experimental and theoretical studies. In vivo, neural mapping experiments on feline animal models illustrate one mode of use for this class of technology. These concepts provide new capabilities for implantable and surgical devices.

Original languageEnglish (US)
Pages (from-to)1-7
Number of pages7
JournalNature Materials
Volume9
Issue number6
DOIs
StatePublished - Jan 1 2010

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Fibroins
silk
Silk
Electronic equipment
Tissue
electronics
animal models
mounting
Mountings
brain
mesh
Brain
Animals
Substrates
Experiments

ASJC Scopus subject areas

  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering

Cite this

Kim, Dae Hyeong ; Viventi, Jonathan ; Amsden, Jason J. ; Xiao, Jianliang ; Vigeland, Leif ; Kim, Yun Soung ; Blanco, Justin A. ; Panilaitis, Bruce ; Frechette, Eric S. ; Contreras, Diego ; Kaplan, David L. ; Omenetto, Fiorenzo G. ; Huang, Yonggang ; Hwang, Keh Chih ; Zakin, Mitchell R. ; Litt, Brian ; Rogers, John A. / Dissolvable films of silk fibroin for ultrathin conformal bio-integrated electronics. In: Nature Materials. 2010 ; Vol. 9, No. 6. pp. 1-7.
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Kim, DH, Viventi, J, Amsden, JJ, Xiao, J, Vigeland, L, Kim, YS, Blanco, JA, Panilaitis, B, Frechette, ES, Contreras, D, Kaplan, DL, Omenetto, FG, Huang, Y, Hwang, KC, Zakin, MR, Litt, B & Rogers, JA 2010, 'Dissolvable films of silk fibroin for ultrathin conformal bio-integrated electronics', Nature Materials, vol. 9, no. 6, pp. 1-7. https://doi.org/10.1038/nmat2745

Dissolvable films of silk fibroin for ultrathin conformal bio-integrated electronics. / Kim, Dae Hyeong; Viventi, Jonathan; Amsden, Jason J.; Xiao, Jianliang; Vigeland, Leif; Kim, Yun Soung; Blanco, Justin A.; Panilaitis, Bruce; Frechette, Eric S.; Contreras, Diego; Kaplan, David L.; Omenetto, Fiorenzo G.; Huang, Yonggang; Hwang, Keh Chih; Zakin, Mitchell R.; Litt, Brian; Rogers, John A.

In: Nature Materials, Vol. 9, No. 6, 01.01.2010, p. 1-7.

Research output: Contribution to journalArticle

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AU - Kaplan, David L.

AU - Omenetto, Fiorenzo G.

AU - Huang, Yonggang

AU - Hwang, Keh Chih

AU - Zakin, Mitchell R.

AU - Litt, Brian

AU - Rogers, John A.

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AB - Electronics that are capable of intimate, non-invasive integration with the soft, curvilinear surfaces of biological tissues offer important opportunities for diagnosing and treating disease and for improving brain/machine interfaces. This article describes a material strategy for a type of bio-interfaced system that relies on ultrathin electronics supported by bioresorbable substrates of silk fibroin. Mounting such devices on tissue and then allowing the silk to dissolve and resorb initiates a spontaneous, conformal wrapping process driven by capillary forces at the biotic/abiotic interface. Specialized mesh designs and ultrathin forms for the electronics ensure minimal stresses on the tissue and highly conformal coverage, even for complex curvilinear surfaces, as confirmed by experimental and theoretical studies. In vivo, neural mapping experiments on feline animal models illustrate one mode of use for this class of technology. These concepts provide new capabilities for implantable and surgical devices.

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Kim DH, Viventi J, Amsden JJ, Xiao J, Vigeland L, Kim YS et al. Dissolvable films of silk fibroin for ultrathin conformal bio-integrated electronics. Nature Materials. 2010 Jan 1;9(6):1-7. https://doi.org/10.1038/nmat2745