Distal initiation and active propagation of action potentials in interneuron dendrites

Marco Martina, Imre Vida, Peter Jonas*

*Corresponding author for this work

Research output: Contribution to journalArticle

237 Citations (Scopus)

Abstract

Fast and reliable activation of inhibitory interneurons is critical for the stability of cortical neuronal networks. Active conductances in dendrites may facilitate interneuron activation, but direct experimental evidence was unavailable. Patch-clamp recordings from dendrites of hippocampal oriens- alveus interneurons revealed high densities of voltage-gated sodium and potassium ion channels. Simultaneous recordings from dendrites and somata suggested that action potential initiation occurs preferentially in the axon with long threshold stimuli, but can be shifted to somatodendritic sites when brief stimuli are applied. After initiation, action potentials propagate over the somatodendritic domain with constant amplitude, high velocity, and reliability, even during high-frequency trains.

Original languageEnglish (US)
Pages (from-to)295-300
Number of pages6
JournalScience
Volume287
Issue number5451
DOIs
StatePublished - Jan 25 2000

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Interneurons
Dendrites
Action Potentials
Sodium Channels
Potassium Channels
Carisoprodol
Axons

ASJC Scopus subject areas

  • General

Cite this

Martina, Marco ; Vida, Imre ; Jonas, Peter. / Distal initiation and active propagation of action potentials in interneuron dendrites. In: Science. 2000 ; Vol. 287, No. 5451. pp. 295-300.
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Distal initiation and active propagation of action potentials in interneuron dendrites. / Martina, Marco; Vida, Imre; Jonas, Peter.

In: Science, Vol. 287, No. 5451, 25.01.2000, p. 295-300.

Research output: Contribution to journalArticle

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