Distance-dependent electron transfer in DNA hairpins

Frederick D Lewis*, Taifeng Wu, Yifan Zhang, Robert L. Letsinger, Scott R. Greenfield, Michael R Wasielewski

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

569 Scopus citations


The distance dependence of photoinduced electron transfer in duplex DNA was determined for a family of synthetic DNA hairpins in which a stilbene dicarboxamide forms a bridge connecting two oligonucleotide arms. Investigation of the fluorescence and transient absorption spectra of these hairpins established that no photoinduced electron transfer occurs for a hairpin that has six deoxyadenosine-deoxythymidine base pairs. However, the introduction of a single deoxyguanosine-deoxycytidine base pair resulted in distance-dependent fluorescence quenching and the formation of the stilbene union radical. Kinetic analysis suggests that duplex DNA is somewhat more effective than proteins as a medium for electron transfer but that it does not function as a molecular wire.

Original languageEnglish (US)
Pages (from-to)673-676
Number of pages4
Issue number5326
StatePublished - Aug 1 1997

ASJC Scopus subject areas

  • Medicine(all)
  • General


Dive into the research topics of 'Distance-dependent electron transfer in DNA hairpins'. Together they form a unique fingerprint.

Cite this