Distinct developmental programs require different levels of Bmp signaling during mouse retinal development

Deepa Murali, Shunichi Yoshikawa, Rebecca R. Corrigan, Daniel J. Plas, Michael C. Crair, Guillermo Oliver, Karen M. Lyons, Yuji Mishina, Yasuhide Furuta*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

101 Scopus citations

Abstract

The Bmp family of secreted signaling molecules is implicated in multiple aspects of embryonic development. However, the cell-type-specific requirements for this signaling pathway are often obscure in the context of complex embryonic tissue interactions. To define the cell-autonomous requirements for Bmp signaling, we have used a Cre-loxP strategy to delete Bmp receptor function specifically within the developing mouse retina. Disruption of a Bmp type I receptor gene, Bmpr1a, leads to no detectable eye abnormality. Further reduction of Bmp receptor activity by removing one functional copy of another Bmp type I receptor gene, Bmpr1b, in the retina-specific Bmpr1a mutant background, results in abnormal retinal dorsoventral patterning. Double mutants completely lacking both of these genes exhibit severe eye defects characterized by reduced growth of embryonic retina and failure of retinal neurogenesis. These studies provide direct genetic evidence that Bmpr1a and Bmpr1b play redundant roles during retinal development, and that different threshold levels of Bmp signaling regulate distinct developmental programs such as patterning, growth and differentiation of the retina.

Original languageEnglish (US)
Pages (from-to)913-923
Number of pages11
JournalDevelopment
Volume132
Issue number5
DOIs
StatePublished - Mar 2005

Keywords

  • Bmp signaling
  • Bmpr1a
  • Bmpr1b
  • Mutant mouse
  • Retinal growth
  • Retinal neurogenesis
  • Retinal patterning

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology

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