Distinct functional and macrostructural brain changes in Parkinson's disease and multiple system atrophy

Peggy J. Planetta, Ajay S. Kurani, Priyank Shukla, Janey Prodoehl, Daniel M. Corcos, Cynthia L. Comella, Nikolaus R. Mcfarland, Michael S. Okun, David E. Vaillancourt*

*Corresponding author for this work

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

Parkinson's disease (PD) and the parkinsonian variant of multiple system atrophy (MSAp) are neurodegenerative disorders that can be difficult to differentiate clinically. This study provides the first characterization of the patterns of task-related functional magnetic resonance imaging (fMRI) changes across the whole brain in MSAp. We used fMRI during a precision grip force task and also performed voxel-based morphometry (VBM) on T1-weighted images in MSAp patients, PD patients, and healthy controls. All groups were matched on age, and the patient groups had comparable motor symptom durations and severities. There were three main findings. First, MSAp and PD had reduced fMRI activation in motor control areas, including the basal ganglia, thalamus, insula, primary sensorimotor and prefrontal cortices, and cerebellum compared with controls. Second, there were no activation differences among the disease groups in the basal ganglia, thalamus, insula, or primary sensorimotor cortices, but PD had more extensive activation deficits throughout the cerebrum compared with MSAp and controls. Third, VBM revealed reduced volume in the basal ganglia, middle and inferior cerebellar peduncles, pons, and throughout the cerebrum in MSAp compared with controls and PD, and additionally throughout the cerebellar cortex and vermis in MSAp compared with controls. Collectively, these results provide the first evidence that fMRI activation is abnormal in the basal ganglia, cerebellum, and cerebrum in MSAp, and that a key distinguishing feature between MSAp and PD is the extensive and widespread volume loss throughout the brain in MSAp. Hum Brain Mapp 36:1165-1179, 2015.

Original languageEnglish (US)
Pages (from-to)1165-1179
Number of pages15
JournalHuman Brain Mapping
Volume36
Issue number3
DOIs
StatePublished - Mar 1 2015

Keywords

  • Atypical parkinsonism
  • Brain atrophy
  • Force
  • Functional magnetic resonance imaging
  • Magnetic resonance imaging
  • Parkinson's disease
  • Voxel-based morphometry

ASJC Scopus subject areas

  • Anatomy
  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging
  • Neurology
  • Clinical Neurology

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  • Cite this

    Planetta, P. J., Kurani, A. S., Shukla, P., Prodoehl, J., Corcos, D. M., Comella, C. L., Mcfarland, N. R., Okun, M. S., & Vaillancourt, D. E. (2015). Distinct functional and macrostructural brain changes in Parkinson's disease and multiple system atrophy. Human Brain Mapping, 36(3), 1165-1179. https://doi.org/10.1002/hbm.22694