Abstract
Acral melanoma is distinct from melanoma of other cutaneous sites, yet there is considerable variation within this category. To better define this variation, we assessed melanomas occurring on dorsal (n = 21), volar (n = 9), and subungual/interdigital (n = 13) acral skin as well as acral nevi (n = 24) for clinical, histologic, and molecular features. Melanomas on dorsal acral surfaces demonstrated clear differences compared with volar and subungual/interdigital melanomas. The latter two groups exhibited significantly less frequent BRAF mutations (P = 0.01), were significantly less likely to have the superficial spreading histologic subtype (P = 0.01), occurred in older patients (P = 0.05), and had more frequent involvement in non-Caucasians (P = 0.01). These differences can be explained by differing levels of UV exposure. Subungual/interdigital melanomas had the most diverse group of oncogenic mutations including PIK3CA (2/13), STK11 (2/13), EGFR (1/13), FGFR3 (1/13), and PTPN11 (1/13). In addition, subungual/interdigital melanomas had a significantly higher frequency of copy number aberrations (67%) than other subgroups (P = 0.02), particularly in CDK4 and cyclin D1, and were less likely to have BRAF mutations or a superficial spreading histologic subtype (P = 0.05) compared with volar acral melanomas. Although based on a limited sample size, differences between volar and subungual/interdigital melanomas in our study may be the result of differing levels of UV exposure.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 384-393 |
| Number of pages | 10 |
| Journal | Journal of Investigative Dermatology |
| Volume | 138 |
| Issue number | 2 |
| DOIs | |
| State | Published - Feb 2018 |
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ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Dermatology
- Cell Biology
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Distinct Patterns of Acral Melanoma Based on Site and Relative Sun Exposure. / Haugh, Alexandra M.; Zhang, Bin; Quan, Victor L.; Garfield, Erin M.; Bubley, Jeffrey A.; Kudalkar, Emily; Verzi, Anna Elisa; Walton, Kara; VandenBoom, Timothy; Merkel, Emily A.; Lee, Christina Y.; Tan, Timothy; Isales, Maria Cristina; Kong, Betty Y.; Wenzel, Alexander T.; Bunick, Christopher G.; Choi, Jaehyuk; Sosman, Jeffrey; Gerami, Pedram.
In: Journal of Investigative Dermatology, Vol. 138, No. 2, 02.2018, p. 384-393.Research output: Contribution to journal › Article
TY - JOUR
T1 - Distinct Patterns of Acral Melanoma Based on Site and Relative Sun Exposure
AU - Haugh, Alexandra M.
AU - Zhang, Bin
AU - Quan, Victor L.
AU - Garfield, Erin M.
AU - Bubley, Jeffrey A.
AU - Kudalkar, Emily
AU - Verzi, Anna Elisa
AU - Walton, Kara
AU - VandenBoom, Timothy
AU - Merkel, Emily A.
AU - Lee, Christina Y.
AU - Tan, Timothy
AU - Isales, Maria Cristina
AU - Kong, Betty Y.
AU - Wenzel, Alexander T.
AU - Bunick, Christopher G.
AU - Choi, Jaehyuk
AU - Sosman, Jeffrey
AU - Gerami, Pedram
PY - 2018/2
Y1 - 2018/2
N2 - Acral melanoma is distinct from melanoma of other cutaneous sites, yet there is considerable variation within this category. To better define this variation, we assessed melanomas occurring on dorsal (n = 21), volar (n = 9), and subungual/interdigital (n = 13) acral skin as well as acral nevi (n = 24) for clinical, histologic, and molecular features. Melanomas on dorsal acral surfaces demonstrated clear differences compared with volar and subungual/interdigital melanomas. The latter two groups exhibited significantly less frequent BRAF mutations (P = 0.01), were significantly less likely to have the superficial spreading histologic subtype (P = 0.01), occurred in older patients (P = 0.05), and had more frequent involvement in non-Caucasians (P = 0.01). These differences can be explained by differing levels of UV exposure. Subungual/interdigital melanomas had the most diverse group of oncogenic mutations including PIK3CA (2/13), STK11 (2/13), EGFR (1/13), FGFR3 (1/13), and PTPN11 (1/13). In addition, subungual/interdigital melanomas had a significantly higher frequency of copy number aberrations (67%) than other subgroups (P = 0.02), particularly in CDK4 and cyclin D1, and were less likely to have BRAF mutations or a superficial spreading histologic subtype (P = 0.05) compared with volar acral melanomas. Although based on a limited sample size, differences between volar and subungual/interdigital melanomas in our study may be the result of differing levels of UV exposure.
AB - Acral melanoma is distinct from melanoma of other cutaneous sites, yet there is considerable variation within this category. To better define this variation, we assessed melanomas occurring on dorsal (n = 21), volar (n = 9), and subungual/interdigital (n = 13) acral skin as well as acral nevi (n = 24) for clinical, histologic, and molecular features. Melanomas on dorsal acral surfaces demonstrated clear differences compared with volar and subungual/interdigital melanomas. The latter two groups exhibited significantly less frequent BRAF mutations (P = 0.01), were significantly less likely to have the superficial spreading histologic subtype (P = 0.01), occurred in older patients (P = 0.05), and had more frequent involvement in non-Caucasians (P = 0.01). These differences can be explained by differing levels of UV exposure. Subungual/interdigital melanomas had the most diverse group of oncogenic mutations including PIK3CA (2/13), STK11 (2/13), EGFR (1/13), FGFR3 (1/13), and PTPN11 (1/13). In addition, subungual/interdigital melanomas had a significantly higher frequency of copy number aberrations (67%) than other subgroups (P = 0.02), particularly in CDK4 and cyclin D1, and were less likely to have BRAF mutations or a superficial spreading histologic subtype (P = 0.05) compared with volar acral melanomas. Although based on a limited sample size, differences between volar and subungual/interdigital melanomas in our study may be the result of differing levels of UV exposure.
UR - http://www.scopus.com/inward/record.url?scp=85041688404&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85041688404&partnerID=8YFLogxK
U2 - 10.1016/j.jid.2017.08.022
DO - 10.1016/j.jid.2017.08.022
M3 - Article
C2 - 28870692
AN - SCOPUS:85041688404
VL - 138
SP - 384
EP - 393
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
SN - 0022-202X
IS - 2
ER -