Distinct prefrontal activations in processing sequence at the sentence and script level: An fMRI study

Sophie Crozier, Angela Sirigu*, Stéphane Lehéricy, Pierre François Van De Moortele, Bernard Pillon, Jordan Grafman, Yves Agid, Bruno Dubois, Denis Lebihan

*Corresponding author for this work

Research output: Contribution to journalArticle

99 Citations (Scopus)

Abstract

Neuropsychological studies have shown that the prefrontal cortex is important in planning and monitoring everyday behaviour. In this study, using functional magnetic resonance imaging (fMRI), we investigated whether specific prefrontal regions are involved in processing a sequence of actions. Subjects were required to perform two different tasks: Script-event order and Sentence-word order. Script sequence and word sequence processing were found to activate partially overlapping areas which are known to be implicated in language processing. In addition, the Script-task activated a large area in the dorsolateral prefrontal cortex (Brodmann area 6 and 8, BA 6 and 8), in both the left and right hemispheres, as well as the left supplementary motor area and left angular gyrus (BA 39). Our results suggest that these prefrontal areas may be more specifically involved in the process of analysing sequential links in the action domain.

Original languageEnglish (US)
Pages (from-to)1469-1476
Number of pages8
JournalNeuropsychologia
Volume37
Issue number13
DOIs
StatePublished - Dec 1 1999

Fingerprint

Prefrontal Cortex
Magnetic Resonance Imaging
Word Processing
Parietal Lobe
Motor Cortex
Language

Keywords

  • Action sequence
  • Frontal lobes
  • Neuropsychology
  • Planning
  • Temporal order

ASJC Scopus subject areas

  • Experimental and Cognitive Psychology
  • Cognitive Neuroscience
  • Behavioral Neuroscience

Cite this

Crozier, S., Sirigu, A., Lehéricy, S., Van De Moortele, P. F., Pillon, B., Grafman, J., ... Lebihan, D. (1999). Distinct prefrontal activations in processing sequence at the sentence and script level: An fMRI study. Neuropsychologia, 37(13), 1469-1476. https://doi.org/10.1016/S0028-3932(99)00054-8
Crozier, Sophie ; Sirigu, Angela ; Lehéricy, Stéphane ; Van De Moortele, Pierre François ; Pillon, Bernard ; Grafman, Jordan ; Agid, Yves ; Dubois, Bruno ; Lebihan, Denis. / Distinct prefrontal activations in processing sequence at the sentence and script level : An fMRI study. In: Neuropsychologia. 1999 ; Vol. 37, No. 13. pp. 1469-1476.
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Crozier, S, Sirigu, A, Lehéricy, S, Van De Moortele, PF, Pillon, B, Grafman, J, Agid, Y, Dubois, B & Lebihan, D 1999, 'Distinct prefrontal activations in processing sequence at the sentence and script level: An fMRI study', Neuropsychologia, vol. 37, no. 13, pp. 1469-1476. https://doi.org/10.1016/S0028-3932(99)00054-8

Distinct prefrontal activations in processing sequence at the sentence and script level : An fMRI study. / Crozier, Sophie; Sirigu, Angela; Lehéricy, Stéphane; Van De Moortele, Pierre François; Pillon, Bernard; Grafman, Jordan; Agid, Yves; Dubois, Bruno; Lebihan, Denis.

In: Neuropsychologia, Vol. 37, No. 13, 01.12.1999, p. 1469-1476.

Research output: Contribution to journalArticle

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AU - Sirigu, Angela

AU - Lehéricy, Stéphane

AU - Van De Moortele, Pierre François

AU - Pillon, Bernard

AU - Grafman, Jordan

AU - Agid, Yves

AU - Dubois, Bruno

AU - Lebihan, Denis

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