Distinct roles of bone morphogenetic proteins in osteogenic differentiation of mesenchymal stem cells

Hue H. Luu, Wen Xin Song, Xiaoji Luo, David Manning, Jinyong Luo, Zhong Liang Deng, Katie A. Sharff, Anthony G. Montag, Rex C. Haydon, Tong Chuan He*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

368 Scopus citations

Abstract

Efficacious bone regeneration could revolutionize the clinical management of many bone and musculoskeletal disorders. Bone morphogenetic proteins (BMPs) can regulate the differentiation of mesenchymal stem cells into cartilage, bone, tendon/ligament, and fat lineages. Early data documented the osteogenic potential of rhBMP2 and rhBMP7/OP-1. However, prior to this work that summarized several of our recent studies, no comprehensive analysis had been undertaken to characterize relative osteogenic activity of all BMPs. Using recombinant adenoviruses expressing 14 BMPs, we have demonstrated that, besides BMP2 and BMP7, BMP6 and BMP9 exhibit the highest osteogenic activity both in vitro and in vivo. We further demonstrated that several BMPs may exert synergistic effect on osteogenic differentiation, and that osteogenic BMPs produce a distinct set of molecular fingerprints during osteogenic differentiation. The reported work should expand our current understanding of BMP functions during osteogenic differentiation. It is conceivable that osteogenic BMPs (i.e., BMP2, 4, 6, 7, and 9) may be used to formulate synergistic pairs among themselves and/or with other less osteogenic BMPs for efficacious bone regeneration in clinical settings.

Original languageEnglish (US)
Pages (from-to)665-677
Number of pages13
JournalJournal of Orthopaedic Research
Volume25
Issue number5
DOIs
StatePublished - May 2007

Keywords

  • Bone morphogenetic protein (BMP) signaling
  • Bone regeneration
  • Marrow stromal stem cell differentiation
  • Osteogenesis
  • Osteogenic differentiation

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine

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