Distinctive expression of Myf5 in relation to differentiation and plasticity of newt muscle cells

Yutaka Imokawa, Phillip B. Gates, Young Tae Chang, Hans Georg Simon, Jeremy P. Brockes*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Regeneration in urodele amphibians such as the newt reflects the local plasticity of differentiated cells. Newt myotubes and myofibres undergo S phase re-entry and cellularisation in the limb blastema, and we have analysed the regulation of Myf5 in relation to these events. Surprisingly, Myf5 was expressed after fusion in cultured newt myotubes and in myofibers of the adult limb, in contrast to its familiar expression in myoblasts in other vertebrates. Its expression was markedly down regulated in cultured newt myotubes after S phase re-entry induced by serum stimulation, as well as by exposure to the trisubstituted purine called myoseverin which induces cellularisation. We have attempted to relate this striking difference from other vertebrates to the requirement for multinucleate urodele muscle cells to contribute to the regeneration blastema.

Original languageEnglish (US)
Pages (from-to)285-291
Number of pages7
JournalInternational Journal of Developmental Biology
Issue number4
StatePublished - Jun 2004


  • Myofiber
  • Myogenin
  • Myoseverin
  • Regeneration
  • Urodele

ASJC Scopus subject areas

  • Embryology
  • Developmental Biology

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