Distribution and characterization of hexose 6-phosphate dehydrogenase in trout

John J. Stegeman*, Erwin Goldberg

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

Electrophoretic analysis of trout liver extracts indicates that an autosomal gene coding for hexose 6-phosphate dehydrogenase (H6P D) in lake trout, Hpd-L, is monomorphic. In brook trout, the gene is polymorphic, having at least three genetic variants termed Hpd-B1, Hpd-B2, and Hpd-B3. F1 hybrid splake exhibit the three expected phenotypes resulting from Hpd-L/Hpd-B1, Hpd-L/Hpd-B2, and Hpd-L/Hpd-B3 genotypes. Trout H6P D is ostensibly a dimer of mol wt 230,000. The characteristics of trout H6P D, including substrate specificity, genetic polymorphism, electrophoretic characteristics, subcellular localization, and tissue distribution are in close agreement with results obtained for mammalian H6P D. We suggest that trout and mammalian H6PDs, X-linked mammalian G6P D, and autosomal avian G6P D arose from a common ancestral type G6P D.

Original languageEnglish (US)
Pages (from-to)579-589
Number of pages11
JournalBiochemical Genetics
Volume5
Issue number6
DOIs
StatePublished - Dec 1 1971

ASJC Scopus subject areas

  • Biochemistry
  • Ecology, Evolution, Behavior and Systematics
  • Molecular Biology
  • Genetics

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