Distribution and projections of nerves with enkephalin-like immunoreactivity in the guinea-pig small intestine

J. B. Furness*, M. Costa, R. J. Miller

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

140 Scopus citations

Abstract

Whole mounts of guinea-pig small intestine were used to examine the distribution of neurons with enkephalin-like immunoreactivity and the effects of microsurgical lesions on these neurons. The enkephalin neurons are intrinsic to the intestine. Cell bodies are found in the myenteric ganglia; processes are in the myenteric plexus, circular muscle (including deep muscular plexus) and submucosa, but not in the mucosa. The cell bodies have one prominent process and several short processes, the latter occasionally are seen to give rise in turn to fine, faint processes. The prominent processes provide fibres to the circular muscle and deep muscular plexus beneath and just anal (up to about 2 mm) to the cell bodies. Fibres in the submucous ganglia come from the overlying myenteric plexus. Orally-directed processes (possibly dendrites) of myentric cell bodies provide the varicose fibres in the myentric ganglia. These processes are 3.5-4 mm long. The enkephalin neurons represent a population of enteric neurons, with a distinct distribution and projections, which does not correspond to any of the other populations of enteric neurons that have been studied.

Original languageEnglish (US)
Pages (from-to)653-664
Number of pages12
JournalNeuroscience
Volume8
Issue number4
DOIs
StatePublished - Jan 1 1983

ASJC Scopus subject areas

  • Neuroscience(all)

Fingerprint Dive into the research topics of 'Distribution and projections of nerves with enkephalin-like immunoreactivity in the guinea-pig small intestine'. Together they form a unique fingerprint.

Cite this