Distribution excretion and metabolism of trifluoperazine methiodide-C14 in rats

C. L. Huang; J. Z. Yeh

doi:10.1016/0028-3908(70)90072-9

Distribution excretion and metabolism of trifluoperazine methiodide-C¹⁴ in rats

C. L. Huang^*, J. Z. Yeh

^*Corresponding author for this work

Pharmacology

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

The majority of the intraperitoneally administered trifluoperazine methiodide-C¹⁴ was excreted in feces by rats. No radioactivity was detected in the expired air of the animals. Blood level was generally low but detectable with a peak level at 1 hr; however the brain level was insignificant against the background at all times. Antimicrobial activities have been demonstrated. Metabolic studies indicated that the majority of this compound was excreted unchanged.

Original language	English (US)
Pages (from-to)	235-242
Number of pages	8
Journal	Neuropharmacology
Volume	9
Issue number	3
DOIs	https://doi.org/10.1016/0028-3908(70)90072-9
State	Published - May 1970

ASJC Scopus subject areas

Pharmacology
Cellular and Molecular Neuroscience

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title = "Distribution excretion and metabolism of trifluoperazine methiodide-C14 in rats",

abstract = "The majority of the intraperitoneally administered trifluoperazine methiodide-C14 was excreted in feces by rats. No radioactivity was detected in the expired air of the animals. Blood level was generally low but detectable with a peak level at 1 hr; however the brain level was insignificant against the background at all times. Antimicrobial activities have been demonstrated. Metabolic studies indicated that the majority of this compound was excreted unchanged.",

author = "Huang, {C. L.} and Yeh, {J. Z.}",

note = "Funding Information: sThis investigation was supported by Public Health Research Service Grant MH-11927 from the National Institute of Mental Health, Bethesda, Maryland. Reported at XXVII International Congress of Pharmaceutical Sciences, Montpellier, France, 7 September, 1967.",

year = "1970",

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T1 - Distribution excretion and metabolism of trifluoperazine methiodide-C14 in rats

AU - Huang, C. L.

AU - Yeh, J. Z.

N1 - Funding Information: sThis investigation was supported by Public Health Research Service Grant MH-11927 from the National Institute of Mental Health, Bethesda, Maryland. Reported at XXVII International Congress of Pharmaceutical Sciences, Montpellier, France, 7 September, 1967.

PY - 1970/5

Y1 - 1970/5

N2 - The majority of the intraperitoneally administered trifluoperazine methiodide-C14 was excreted in feces by rats. No radioactivity was detected in the expired air of the animals. Blood level was generally low but detectable with a peak level at 1 hr; however the brain level was insignificant against the background at all times. Antimicrobial activities have been demonstrated. Metabolic studies indicated that the majority of this compound was excreted unchanged.

AB - The majority of the intraperitoneally administered trifluoperazine methiodide-C14 was excreted in feces by rats. No radioactivity was detected in the expired air of the animals. Blood level was generally low but detectable with a peak level at 1 hr; however the brain level was insignificant against the background at all times. Antimicrobial activities have been demonstrated. Metabolic studies indicated that the majority of this compound was excreted unchanged.

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JO - Neuropharmacology

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IS - 3

ER -

Distribution excretion and metabolism of trifluoperazine methiodide-C¹⁴ in rats

Abstract

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