Distribution of pulmonary vascular resistance during lactic acid infusion in dogs

K. W. Presberg*, J. I. Sznajder, J. Melendres, T. Lewis, C. Abrahams, L. D H Wood

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


We sought to determine the longitudinal distribution of pulmonary vascular resistance (PVR) in acute lactic acidosis utilizing pulmonary artery and vein balloon occlusion techniques (Holloway et al. J. Appl. Physiol. 54: 840-851, 1983). In anesthetized dogs, both a systemic vein (I-V) infusion and systemic artery (I-A) infusion of L-lactic acid were studied to control for potential effects of factors other than pH on PVR. During progressive I-A infusion (n = 9) to a pH of 6.94 ± 0.06 there was no significant change in PVR or its distribution. In contrast, I-V infusion (n = 9) to a pH of 7.08 ± 0.09 increased median PVR from 3.6 to 21.7 mmHg·l-1·min (P < 0.001), due to an increase in middle segment resistance (0.0-15.4 mmHg·l-1·min, P < 0.02). Examination by light and electron microscopy demonstrated pulmonary capillary obstruction with hemolyzed erythrocyte (RBC) membranes with I-V infusion, but representative I-A animals did not demonstrate these findings. Conceivably, the systemic vascular bed filtered the fragmented RBC membranes in the I-A model, but this microvascular obstruction with altered RBCs and RBC fragments caused the pulmonary hypertension observed in the I-V infusion. We conclude that lactic acidosis does not increase pulmonary vascular tone in dogs, a finding compatible with most previous studies in which observed increases in PVR may be attributed to other effects from I-V acid infusion on circulating blood elements.

Original languageEnglish (US)
Pages (from-to)1328-1336
Number of pages9
JournalJournal of applied physiology
Issue number4
StatePublished - 1990


  • hemolysis
  • metabolic acidosis
  • occlusion technique
  • pulmonary hypertension

ASJC Scopus subject areas

  • Medicine(all)


Dive into the research topics of 'Distribution of pulmonary vascular resistance during lactic acid infusion in dogs'. Together they form a unique fingerprint.

Cite this