Abstract
We have modeled the left lower dog lung lobe as three serial compartments, each containing resistance (R) and compliance (C). The intracompartmental arrangement of R and C was chosen to permit their evaluation from pressure data obtained following occlusion of the venous outflow. We found that two mathematically distinct models permitted evaluation of the distribution of R and C. The models were complementary in that when used together the R and C of the three compartments could be determined. The central compartment had 46% of the lobar vascular resistance and 75% of the lobar vascular compliance under control conditions. We found that serotonin and histamine, which increased the resistance proximal and distal to the central compartment, respectively, did not increase the central resistance. Therefore, we conclude that the central compartment includes the capillary bed. The equilibrium pressure (P(d)), obtained when arterial inflow and venous outflow were simultaneously occluded, was in close agreement with the average preocclusion pressure of the central compartment, indicating that P(d) is close to the pulmonary microvascular pressure.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 158-168 |
| Number of pages | 11 |
| Journal | Journal of Applied Physiology Respiratory Environmental and Exercise Physiology |
| Volume | 53 |
| Issue number | 1 |
| State | Published - Jan 1 1982 |
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ASJC Scopus subject areas
- Endocrinology
- Physiology
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Distribution of vascular resistance and compliance in a dog lung lobe. / Linehan, J. H.; Dawson, C. A.; Rickaby, D. A.
In: Journal of Applied Physiology Respiratory Environmental and Exercise Physiology, Vol. 53, No. 1, 01.01.1982, p. 158-168.Research output: Contribution to journal › Article
TY - JOUR
T1 - Distribution of vascular resistance and compliance in a dog lung lobe
AU - Linehan, J. H.
AU - Dawson, C. A.
AU - Rickaby, D. A.
PY - 1982/1/1
Y1 - 1982/1/1
N2 - We have modeled the left lower dog lung lobe as three serial compartments, each containing resistance (R) and compliance (C). The intracompartmental arrangement of R and C was chosen to permit their evaluation from pressure data obtained following occlusion of the venous outflow. We found that two mathematically distinct models permitted evaluation of the distribution of R and C. The models were complementary in that when used together the R and C of the three compartments could be determined. The central compartment had 46% of the lobar vascular resistance and 75% of the lobar vascular compliance under control conditions. We found that serotonin and histamine, which increased the resistance proximal and distal to the central compartment, respectively, did not increase the central resistance. Therefore, we conclude that the central compartment includes the capillary bed. The equilibrium pressure (P(d)), obtained when arterial inflow and venous outflow were simultaneously occluded, was in close agreement with the average preocclusion pressure of the central compartment, indicating that P(d) is close to the pulmonary microvascular pressure.
AB - We have modeled the left lower dog lung lobe as three serial compartments, each containing resistance (R) and compliance (C). The intracompartmental arrangement of R and C was chosen to permit their evaluation from pressure data obtained following occlusion of the venous outflow. We found that two mathematically distinct models permitted evaluation of the distribution of R and C. The models were complementary in that when used together the R and C of the three compartments could be determined. The central compartment had 46% of the lobar vascular resistance and 75% of the lobar vascular compliance under control conditions. We found that serotonin and histamine, which increased the resistance proximal and distal to the central compartment, respectively, did not increase the central resistance. Therefore, we conclude that the central compartment includes the capillary bed. The equilibrium pressure (P(d)), obtained when arterial inflow and venous outflow were simultaneously occluded, was in close agreement with the average preocclusion pressure of the central compartment, indicating that P(d) is close to the pulmonary microvascular pressure.
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UR - http://www.scopus.com/inward/citedby.url?scp=0019947002&partnerID=8YFLogxK
M3 - Article
C2 - 7118629
AN - SCOPUS:0019947002
VL - 53
SP - 158
EP - 168
JO - Journal of Applied Physiology
JF - Journal of Applied Physiology
SN - 8750-7587
IS - 1
ER -