Disturbances of sleep perception in a group of multiple sclerosis patients: A case report

Hrayr Attarian*, Garrick Applebee, Catherine Schuman

*Corresponding author for this work

Research output: Contribution to journalArticle

2 Scopus citations


Sleep misperception, whether severe enough to qualify as paradoxical insomnia or not, is common in a number of neurological and psychiatric conditions. The objective was to assess sleep perception in a group of multiple sclerosis (MS) patients. As part of an Institutional Review Board (IRB) approved trial designed to assess the efficacy of eszopiclone versus placebo in improving MS patients' sleep continuity, we observed a pattern of both paradoxical and reverse paradoxical insomnia in a small number of participants. Eight participants (26.7%) had some degree of misperception at some point during the study. Six (20%) had reverse paradoxical insomnia and two (6.7%) had paradoxical insomnia. This is a preliminary observation that we hope will increase awareness of the condition of misperception of sleep in subjects with MS.

Original languageEnglish (US)
Pages (from-to)124-126
Number of pages3
JournalClinical and Experimental Neuroimmunology
Issue number3
StatePublished - Sep 1 2010


  • Actigraphyl
  • Multiple sclerosis
  • Paradoxical insomnia
  • Reverse paradoxical insomnia
  • Sleep misperception

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Immunology
  • Immunology and Microbiology (miscellaneous)
  • Clinical Neurology

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