Diuretic pharmacokinetics and pharmacodynamics in infants from the analysis of urinary drug excretion data

New equations are described that permit the determination of both drug disposition and diuretic response of luminally active diuretics from the analysis of urinary drug excretion data. The methods represent a convenient and logical approach for the clinical study of the disposition of renally excreted drugs that are described by a one-compartment open model and the response of luminally active diuretics that exhibit a linear diuretic excretion rate-response relationship. The validity of the approach is verified in a study of furosemide disposition and response in 10 infants. These methods will facilitate the studies of diuretics in newborn and young infants and other populations that are difficult to study by conventional methodology.