Diurnal salivary cortisol and urinary catecholamines are associated with diabetes mellitus: The Multi-Ethnic Study of Atherosclerosis

Shivam Champaneri; Xiaoqiang Xu; Mercedes R. Carnethon; Alain G. Bertoni; Teresa Seeman; Ana Diez Roux; Sherita Hill Golden

doi:10.1016/j.metabol.2011.11.006

Diurnal salivary cortisol and urinary catecholamines are associated with diabetes mellitus: The Multi-Ethnic Study of Atherosclerosis

Shivam Champaneri, Xiaoqiang Xu, Mercedes R. Carnethon, Alain G. Bertoni, Teresa Seeman, Ana Diez Roux, Sherita Hill Golden^*

^*Corresponding author for this work

Preventive Medicine

Research output: Contribution to journal › Article › peer-review

66 Scopus citations

Abstract

The objective was to examine the cross-sectional association of diurnal salivary cortisol curve components and urinary catecholamines with diabetes status. Up to 18 salivary cortisol samples over 3 days and overnight urinary catecholamines were collected from 1002 participants in the Multi-Ethnic Study of Atherosclerosis. Diabetes was defined as a fasting blood glucose of at least 126 mg/dL or medication use. Cortisol curve measures included awakening cortisol, cortisol awakening response, early decline, late decline, and cortisol area under the curve (AUC). Urinary catecholamines included epinephrine, norepinephrine, and dopamine. Participants with diabetes had significantly lower cortisol awakening response (β = -0.19; 95% confidence interval [CI], -0.34 to -0.04) than those without diabetes in multivariable models. Whereas men with diabetes had a nonsignificant trend toward lower total AUC (β = -1.56; 95% CI, -3.93 to 0.80), women with diabetes had significantly higher total AUC (β = 2.62; 95% CI, 0.72 to 4.51) (P =.02 for interaction) compared with those without diabetes. Men but not women with diabetes had significantly lower urinary catecholamines compared with those without diabetes (P <.05). Diabetes is associated with neuroendocrine dysregulation, which may differ by sex. Further studies are needed to determine the role of the neuroendocrine system in the pathophysiology of diabetes.

Original language	English (US)
Pages (from-to)	986-995
Number of pages	10
Journal	Metabolism: Clinical and Experimental
Volume	61
Issue number	7
DOIs	https://doi.org/10.1016/j.metabol.2011.11.006
State	Published - Jul 2012

Funding

SC, XX, MC, AB, and TS have nothing to declare. ADR is funded by a research grant from the National Institutes of Health. SHG is funded by National Institutes of Health and National Heart, Lung, and Blood Institute contracts that support MESA and MESA Stress. MESA was supported by contracts NO1-HC-95159 through NO1-HC-95165 and NO1-HC-95169 from the National Heart, Lung, and Blood Institute . MESA Stress Study was supported by RO1 HL076831 (PI: Dr Diez-Roux). Dr Golden was supported by a Patient-Oriented Mentored Scientist Award through the National Institute of Diabetes, Digestive, and Kidney Diseases, Bethesda, MD ( 5 K23 DK071565 ). Dr Champaneri was supported by a training grant (T32 Ruth L. Kirschstein National Research Service Award).

ASJC Scopus subject areas

Endocrinology
Endocrinology, Diabetes and Metabolism

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.metabol.2011.11.006

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@article{241fe96f03c84d0aa3075f35a86c5728,

title = "Diurnal salivary cortisol and urinary catecholamines are associated with diabetes mellitus: The Multi-Ethnic Study of Atherosclerosis",

abstract = "The objective was to examine the cross-sectional association of diurnal salivary cortisol curve components and urinary catecholamines with diabetes status. Up to 18 salivary cortisol samples over 3 days and overnight urinary catecholamines were collected from 1002 participants in the Multi-Ethnic Study of Atherosclerosis. Diabetes was defined as a fasting blood glucose of at least 126 mg/dL or medication use. Cortisol curve measures included awakening cortisol, cortisol awakening response, early decline, late decline, and cortisol area under the curve (AUC). Urinary catecholamines included epinephrine, norepinephrine, and dopamine. Participants with diabetes had significantly lower cortisol awakening response (β = -0.19; 95% confidence interval [CI], -0.34 to -0.04) than those without diabetes in multivariable models. Whereas men with diabetes had a nonsignificant trend toward lower total AUC (β = -1.56; 95% CI, -3.93 to 0.80), women with diabetes had significantly higher total AUC (β = 2.62; 95% CI, 0.72 to 4.51) (P =.02 for interaction) compared with those without diabetes. Men but not women with diabetes had significantly lower urinary catecholamines compared with those without diabetes (P <.05). Diabetes is associated with neuroendocrine dysregulation, which may differ by sex. Further studies are needed to determine the role of the neuroendocrine system in the pathophysiology of diabetes.",

author = "Shivam Champaneri and Xiaoqiang Xu and Carnethon, {Mercedes R.} and Bertoni, {Alain G.} and Teresa Seeman and Roux, {Ana Diez} and Golden, {Sherita Hill}",

note = "Funding Information: SC, XX, MC, AB, and TS have nothing to declare. ADR is funded by a research grant from the National Institutes of Health. SHG is funded by National Institutes of Health and National Heart, Lung, and Blood Institute contracts that support MESA and MESA Stress. Funding Information: MESA was supported by contracts NO1-HC-95159 through NO1-HC-95165 and NO1-HC-95169 from the National Heart, Lung, and Blood Institute . MESA Stress Study was supported by RO1 HL076831 (PI: Dr Diez-Roux). Dr Golden was supported by a Patient-Oriented Mentored Scientist Award through the National Institute of Diabetes, Digestive, and Kidney Diseases, Bethesda, MD ( 5 K23 DK071565 ). Dr Champaneri was supported by a training grant (T32 Ruth L. Kirschstein National Research Service Award). ",

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AU - Bertoni, Alain G.

AU - Seeman, Teresa

AU - Roux, Ana Diez

AU - Golden, Sherita Hill

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N2 - The objective was to examine the cross-sectional association of diurnal salivary cortisol curve components and urinary catecholamines with diabetes status. Up to 18 salivary cortisol samples over 3 days and overnight urinary catecholamines were collected from 1002 participants in the Multi-Ethnic Study of Atherosclerosis. Diabetes was defined as a fasting blood glucose of at least 126 mg/dL or medication use. Cortisol curve measures included awakening cortisol, cortisol awakening response, early decline, late decline, and cortisol area under the curve (AUC). Urinary catecholamines included epinephrine, norepinephrine, and dopamine. Participants with diabetes had significantly lower cortisol awakening response (β = -0.19; 95% confidence interval [CI], -0.34 to -0.04) than those without diabetes in multivariable models. Whereas men with diabetes had a nonsignificant trend toward lower total AUC (β = -1.56; 95% CI, -3.93 to 0.80), women with diabetes had significantly higher total AUC (β = 2.62; 95% CI, 0.72 to 4.51) (P =.02 for interaction) compared with those without diabetes. Men but not women with diabetes had significantly lower urinary catecholamines compared with those without diabetes (P <.05). Diabetes is associated with neuroendocrine dysregulation, which may differ by sex. Further studies are needed to determine the role of the neuroendocrine system in the pathophysiology of diabetes.

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Diurnal salivary cortisol and urinary catecholamines are associated with diabetes mellitus: The Multi-Ethnic Study of Atherosclerosis

Abstract

Funding

ASJC Scopus subject areas

UN SDGs

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