TY - JOUR
T1 - Diurnal salivary cortisol and urinary catecholamines are associated with diabetes mellitus
T2 - The Multi-Ethnic Study of Atherosclerosis
AU - Champaneri, Shivam
AU - Xu, Xiaoqiang
AU - Carnethon, Mercedes R.
AU - Bertoni, Alain G.
AU - Seeman, Teresa
AU - Roux, Ana Diez
AU - Golden, Sherita Hill
N1 - Funding Information:
SC, XX, MC, AB, and TS have nothing to declare. ADR is funded by a research grant from the National Institutes of Health. SHG is funded by National Institutes of Health and National Heart, Lung, and Blood Institute contracts that support MESA and MESA Stress.
Funding Information:
MESA was supported by contracts NO1-HC-95159 through NO1-HC-95165 and NO1-HC-95169 from the National Heart, Lung, and Blood Institute . MESA Stress Study was supported by RO1 HL076831 (PI: Dr Diez-Roux). Dr Golden was supported by a Patient-Oriented Mentored Scientist Award through the National Institute of Diabetes, Digestive, and Kidney Diseases, Bethesda, MD ( 5 K23 DK071565 ). Dr Champaneri was supported by a training grant (T32 Ruth L. Kirschstein National Research Service Award).
PY - 2012/7
Y1 - 2012/7
N2 - The objective was to examine the cross-sectional association of diurnal salivary cortisol curve components and urinary catecholamines with diabetes status. Up to 18 salivary cortisol samples over 3 days and overnight urinary catecholamines were collected from 1002 participants in the Multi-Ethnic Study of Atherosclerosis. Diabetes was defined as a fasting blood glucose of at least 126 mg/dL or medication use. Cortisol curve measures included awakening cortisol, cortisol awakening response, early decline, late decline, and cortisol area under the curve (AUC). Urinary catecholamines included epinephrine, norepinephrine, and dopamine. Participants with diabetes had significantly lower cortisol awakening response (β = -0.19; 95% confidence interval [CI], -0.34 to -0.04) than those without diabetes in multivariable models. Whereas men with diabetes had a nonsignificant trend toward lower total AUC (β = -1.56; 95% CI, -3.93 to 0.80), women with diabetes had significantly higher total AUC (β = 2.62; 95% CI, 0.72 to 4.51) (P =.02 for interaction) compared with those without diabetes. Men but not women with diabetes had significantly lower urinary catecholamines compared with those without diabetes (P <.05). Diabetes is associated with neuroendocrine dysregulation, which may differ by sex. Further studies are needed to determine the role of the neuroendocrine system in the pathophysiology of diabetes.
AB - The objective was to examine the cross-sectional association of diurnal salivary cortisol curve components and urinary catecholamines with diabetes status. Up to 18 salivary cortisol samples over 3 days and overnight urinary catecholamines were collected from 1002 participants in the Multi-Ethnic Study of Atherosclerosis. Diabetes was defined as a fasting blood glucose of at least 126 mg/dL or medication use. Cortisol curve measures included awakening cortisol, cortisol awakening response, early decline, late decline, and cortisol area under the curve (AUC). Urinary catecholamines included epinephrine, norepinephrine, and dopamine. Participants with diabetes had significantly lower cortisol awakening response (β = -0.19; 95% confidence interval [CI], -0.34 to -0.04) than those without diabetes in multivariable models. Whereas men with diabetes had a nonsignificant trend toward lower total AUC (β = -1.56; 95% CI, -3.93 to 0.80), women with diabetes had significantly higher total AUC (β = 2.62; 95% CI, 0.72 to 4.51) (P =.02 for interaction) compared with those without diabetes. Men but not women with diabetes had significantly lower urinary catecholamines compared with those without diabetes (P <.05). Diabetes is associated with neuroendocrine dysregulation, which may differ by sex. Further studies are needed to determine the role of the neuroendocrine system in the pathophysiology of diabetes.
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U2 - 10.1016/j.metabol.2011.11.006
DO - 10.1016/j.metabol.2011.11.006
M3 - Article
C2 - 22209664
AN - SCOPUS:84862123233
SN - 0026-0495
VL - 61
SP - 986
EP - 995
JO - Metabolism: Clinical and Experimental
JF - Metabolism: Clinical and Experimental
IS - 7
ER -