Diurnal variations in maternal and fetal steroids in pregnant rhesus monkeys

J. R G Challis, M. Socol, Y. Murata, F. A. Manning, C. B. Martin

Research output: Contribution to journalArticlepeer-review

33 Scopus citations

Abstract

To examine diurnal changes in maternal and fetal steroids in chronically catheterized pregnant rhesus monkeys, the authors have measured cortisol (F), progesterone (P4), estrone, and estradiol in maternal blood and F, P4, and dehydroepiandrosterone sulphate (DHAS) in simultaneous samples of fetal blood taken in the morning (07.00-10.00 hr) and in the evening (17.00-21.00 hr). In the mother, the concentrations of F, estradiol, and estrone were higher in the morning than in the evening. In contrast, progesterone was higher in evening than in morning samples. In fetal blood, there was no significant morning-evening difference for F; however, the concentrations of P4 and DHAS were higher in the evening than in the morning samples. In 3 individual monkeys, the concentrations of P4 and DHAS in serial samples of fetal blood were correlated. The authors conclude (1) that there are marked diurnal changes in the concentration of several steroids in samples of maternal and fetal blood and (2) that the concentration of F in maternal blood shows the opposite pattern to that of possible fetal adrenal steroids in fetal blood.

Original languageEnglish (US)
Pages (from-to)1283-1288
Number of pages6
JournalEndocrinology
Volume106
Issue number4
StatePublished - May 23 1980

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

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