DNA damage and metabolic mechanisms of cancer drug resistance

Deanna Tiek*, Shi Yuan Cheng

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations


Cancer drug resistance is one of the main barriers to overcome to ensure durable treatment responses. While many pivotal advances have been made in first combination therapies, then targeted therapies, and now broadening out to immunomodulatory drugs or metabolic targeting compounds, drug resistance is still ultimately universally fatal. In this brief review, we will discuss different strategies that have been used to fight drug resistance from synthetic lethality to tumor microenvironment modulation, focusing on the DNA damage response and tumor metabolism both within tumor cells and their surrounding microenvironment. In this way, with a better understanding of both targetable mutations in combination with the metabolism, smarter drugs may be designed to combat cancer drug resistance.

Original languageEnglish (US)
Pages (from-to)368-379
Number of pages12
JournalCancer Drug Resistance
Issue number2
StatePublished - 2022


  • Cancer drug resistance
  • DNA damage
  • DNA repair
  • drug resistance
  • hypoxia
  • metabolism
  • overcoming resistance
  • synthetic lethality

ASJC Scopus subject areas

  • Cancer Research
  • Pharmacology (medical)


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