DNA manipulators: Caught in the act

Anita Changela*, Kay Perry, Bhupesh Taneja, Alfonso Mondragón

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

8 Scopus citations


DNA is a dynamic molecule that undergoes constant changes in the cell through interactions with numerous proteins. Several classes of enzyme are specialized in promoting DNA rearrangements, including site-specific recombinases, DNA helicases, transposases and DNA topoisomerases. Recent structures of protein-DNA reaction intermediates trapped in various states of DNA remodeling, complemented by biochemical and biophysical functional studies, have enhanced our understanding of their respective mechanistic pathways.

Original languageEnglish (US)
Pages (from-to)15-22
Number of pages8
JournalCurrent Opinion in Structural Biology
Issue number1
StatePublished - Feb 1 2003

ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology


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