DNA manipulators: Caught in the act

Anita Changela; Kay Perry; Bhupesh Taneja; Alfonso Mondragón

doi:10.1016/S0959-440X(02)00006-4

DNA manipulators: Caught in the act

Anita Changela^*, Kay Perry, Bhupesh Taneja, Alfonso Mondragón

^*Corresponding author for this work

Molecular Biosciences

Research output: Contribution to journal › Review article › peer-review

8 Scopus citations

Abstract

DNA is a dynamic molecule that undergoes constant changes in the cell through interactions with numerous proteins. Several classes of enzyme are specialized in promoting DNA rearrangements, including site-specific recombinases, DNA helicases, transposases and DNA topoisomerases. Recent structures of protein-DNA reaction intermediates trapped in various states of DNA remodeling, complemented by biochemical and biophysical functional studies, have enhanced our understanding of their respective mechanistic pathways.

Original language	English (US)
Pages (from-to)	15-22
Number of pages	8
Journal	Current Opinion in Structural Biology
Volume	13
Issue number	1
DOIs	https://doi.org/10.1016/S0959-440X(02)00006-4
State	Published - Feb 1 2003

Funding

Work was supported by a grant from the National Institutes of Health (GM51350) to AM.

ASJC Scopus subject areas

Structural Biology
Molecular Biology

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10.1016/S0959-440X(02)00006-4

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abstract = "DNA is a dynamic molecule that undergoes constant changes in the cell through interactions with numerous proteins. Several classes of enzyme are specialized in promoting DNA rearrangements, including site-specific recombinases, DNA helicases, transposases and DNA topoisomerases. Recent structures of protein-DNA reaction intermediates trapped in various states of DNA remodeling, complemented by biochemical and biophysical functional studies, have enhanced our understanding of their respective mechanistic pathways.",

author = "Anita Changela and Kay Perry and Bhupesh Taneja and Alfonso Mondrag{\'o}n",

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AU - Changela, Anita

AU - Perry, Kay

AU - Taneja, Bhupesh

AU - Mondragón, Alfonso

N1 - Funding Information: Work was supported by a grant from the National Institutes of Health (GM51350) to AM.

PY - 2003/2/1

Y1 - 2003/2/1

N2 - DNA is a dynamic molecule that undergoes constant changes in the cell through interactions with numerous proteins. Several classes of enzyme are specialized in promoting DNA rearrangements, including site-specific recombinases, DNA helicases, transposases and DNA topoisomerases. Recent structures of protein-DNA reaction intermediates trapped in various states of DNA remodeling, complemented by biochemical and biophysical functional studies, have enhanced our understanding of their respective mechanistic pathways.

AB - DNA is a dynamic molecule that undergoes constant changes in the cell through interactions with numerous proteins. Several classes of enzyme are specialized in promoting DNA rearrangements, including site-specific recombinases, DNA helicases, transposases and DNA topoisomerases. Recent structures of protein-DNA reaction intermediates trapped in various states of DNA remodeling, complemented by biochemical and biophysical functional studies, have enhanced our understanding of their respective mechanistic pathways.

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DNA manipulators: Caught in the act

Abstract

Funding

ASJC Scopus subject areas

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