TY - JOUR
T1 - DNA methylation as a transcriptional regulator of the immune system
AU - Morales-Nebreda, Luisa
AU - McLafferty, Fred S.
AU - Singer, Benjamin D.
N1 - Funding Information:
BDS is supported by NIH/NIAID grant U19AI135964 , NIH/NHLBI grant K08HL128867 , the Parker B. Francis Research Opportunity Award of the Francis Family Foundation, and the Eleanor Wood-Prince Grants Initiative of the Woman's Board of Northwestern Memorial Hospital.
Funding Information:
BDS is supported by NIH/NIAID grant U19AI135964, NIH/NHLBI grant K08HL128867, the Parker B. Francis Research Opportunity Award of the Francis Family Foundation, and the Eleanor Wood-Prince Grants Initiative of the Woman's Board of Northwestern Memorial Hospital.
Publisher Copyright:
© 2018
PY - 2019/2
Y1 - 2019/2
N2 - DNA methylation is a dynamic epigenetic modification with a prominent role in determining mammalian cell development, lineage identity, and transcriptional regulation. Primarily linked to gene silencing, novel technologies have expanded the ability to measure DNA methylation on a genome-wide scale and uncover context-dependent regulatory roles. The immune system is a prototypic model for studying how DNA methylation patterning modulates cell type- and stimulus-specific transcriptional programs. Preservation of host defense and organ homeostasis depends on fine-tuned epigenetic mechanisms controlling myeloid and lymphoid cell differentiation and function, which shape innate and adaptive immune responses. Dysregulation of these processes can lead to human immune system pathology as seen in blood malignancies, infections, and autoimmune diseases. Identification of distinct epigenotypes linked to pathogenesis carries the potential to validate therapeutic targets in disease prevention and management.
AB - DNA methylation is a dynamic epigenetic modification with a prominent role in determining mammalian cell development, lineage identity, and transcriptional regulation. Primarily linked to gene silencing, novel technologies have expanded the ability to measure DNA methylation on a genome-wide scale and uncover context-dependent regulatory roles. The immune system is a prototypic model for studying how DNA methylation patterning modulates cell type- and stimulus-specific transcriptional programs. Preservation of host defense and organ homeostasis depends on fine-tuned epigenetic mechanisms controlling myeloid and lymphoid cell differentiation and function, which shape innate and adaptive immune responses. Dysregulation of these processes can lead to human immune system pathology as seen in blood malignancies, infections, and autoimmune diseases. Identification of distinct epigenotypes linked to pathogenesis carries the potential to validate therapeutic targets in disease prevention and management.
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U2 - 10.1016/j.trsl.2018.08.001
DO - 10.1016/j.trsl.2018.08.001
M3 - Review article
C2 - 30170004
AN - SCOPUS:85052986725
VL - 204
SP - 1
EP - 18
JO - Translational Research
JF - Translational Research
SN - 1931-5244
ER -
