DNA-nanoparticle micelles as supramolecular fluorogenic substrates enabling catalytic signal amplification and detection by DNAzyme probes

Miao Ping Chien, Matthew P. Thompson, Nathan C. Gianneschi

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

Catalytic DNA molecules have tremendous potential in propagating detection events via nucleic acid sequence selective signal amplification. However, they suffer from product inhibition limiting their widespread utility. Herein, this limitation is overcome utilizing a novel fluorogenic substrate design consisting of cooperatively assembled DNA-nanoparticle micelles.

Original languageEnglish (US)
Pages (from-to)167-169
Number of pages3
JournalChemical Communications
Volume47
Issue number1
DOIs
StatePublished - Jan 7 2011

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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