DNA-Nanoparticle Superlattices Formed from Anisotropic Building Blocks

Matthew R. Jones; Robert J. Macfarlane; Byeongdu Lee; Jian Zhang; Kaylie L. Young; Andrew J. Senesi; Chad A. Mirkin

doi:10.1201/9781003056690-31

DNA-Nanoparticle Superlattices Formed from Anisotropic Building Blocks

Matthew R. Jones, Robert J. Macfarlane, Byeongdu Lee, Jian Zhang, Kaylie L. Young, Andrew J. Senesi, Chad A. Mirkin^*

^*Corresponding author for this work

Chemistry

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Hybridization interactions between DNA-functionalized nanoparticles (DNA-NPs) can be used to program the crystallization behavior of superlattices, yielding access to complex three-dimensional structures with more than 30 different lattice symmetries. This chapter provides a comprehensive approach to study the role of repulsion in the assembly behavior of DNA-NPs, enabling the calculation of interparticle interaction potentials based on experimental results. Two different means to assemble DNA-NPs, Watson-Crick base-pairing interactions and depletion interactions, are used and the salt concentration is systematically varied to study the effective interactions in DNA-NP superlattices. The chapter finds that the gap distance between adjacent DNA-NPs follows a simple power law dependence on solution ionic strength regardless of the type of attractive forces present. This result suggests that the observed trend is driven by repulsive interactions. To better understand such behavior, The chapter proposes a mean-field model that provides a mathematical description for the observed trend.

Original language	English (US)
Title of host publication	Spherical Nucleic Acids
Subtitle of host publication	Volume 2
Publisher	Jenny Stanford Publishing
Pages	601-613
Number of pages	13
Volume	2
ISBN (Electronic)	9781000092363
ISBN (Print)	9789814877220
DOIs	https://doi.org/10.1201/9781003056690-31
State	Published - Jan 1 2021

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology
General Engineering
General Chemistry

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abstract = "Hybridization interactions between DNA-functionalized nanoparticles (DNA-NPs) can be used to program the crystallization behavior of superlattices, yielding access to complex three-dimensional structures with more than 30 different lattice symmetries. This chapter provides a comprehensive approach to study the role of repulsion in the assembly behavior of DNA-NPs, enabling the calculation of interparticle interaction potentials based on experimental results. Two different means to assemble DNA-NPs, Watson-Crick base-pairing interactions and depletion interactions, are used and the salt concentration is systematically varied to study the effective interactions in DNA-NP superlattices. The chapter finds that the gap distance between adjacent DNA-NPs follows a simple power law dependence on solution ionic strength regardless of the type of attractive forces present. This result suggests that the observed trend is driven by repulsive interactions. To better understand such behavior, The chapter proposes a mean-field model that provides a mathematical description for the observed trend.",

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AU - Jones, Matthew R.

AU - Macfarlane, Robert J.

AU - Lee, Byeongdu

AU - Zhang, Jian

AU - Young, Kaylie L.

AU - Senesi, Andrew J.

AU - Mirkin, Chad A.

PY - 2021/1/1

Y1 - 2021/1/1

N2 - Hybridization interactions between DNA-functionalized nanoparticles (DNA-NPs) can be used to program the crystallization behavior of superlattices, yielding access to complex three-dimensional structures with more than 30 different lattice symmetries. This chapter provides a comprehensive approach to study the role of repulsion in the assembly behavior of DNA-NPs, enabling the calculation of interparticle interaction potentials based on experimental results. Two different means to assemble DNA-NPs, Watson-Crick base-pairing interactions and depletion interactions, are used and the salt concentration is systematically varied to study the effective interactions in DNA-NP superlattices. The chapter finds that the gap distance between adjacent DNA-NPs follows a simple power law dependence on solution ionic strength regardless of the type of attractive forces present. This result suggests that the observed trend is driven by repulsive interactions. To better understand such behavior, The chapter proposes a mean-field model that provides a mathematical description for the observed trend.

AB - Hybridization interactions between DNA-functionalized nanoparticles (DNA-NPs) can be used to program the crystallization behavior of superlattices, yielding access to complex three-dimensional structures with more than 30 different lattice symmetries. This chapter provides a comprehensive approach to study the role of repulsion in the assembly behavior of DNA-NPs, enabling the calculation of interparticle interaction potentials based on experimental results. Two different means to assemble DNA-NPs, Watson-Crick base-pairing interactions and depletion interactions, are used and the salt concentration is systematically varied to study the effective interactions in DNA-NP superlattices. The chapter finds that the gap distance between adjacent DNA-NPs follows a simple power law dependence on solution ionic strength regardless of the type of attractive forces present. This result suggests that the observed trend is driven by repulsive interactions. To better understand such behavior, The chapter proposes a mean-field model that provides a mathematical description for the observed trend.

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DNA-Nanoparticle Superlattices Formed from Anisotropic Building Blocks

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ASJC Scopus subject areas

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