Reparativnyǐ sintez DNK v kul'turakh kletok pecheni mysheǐ s razlicnoǐ predraspolozhennost'iu k spontannomu gepatokantserogenezu.

Translated title of the contribution: DNA reparative synthesis in liver cell cultures from mice with various susceptibilities to spontaneous hepatic carcinogenesis

I. V. Budunova*, G. A. Belitskiǐ

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Ultra-violet radiation-induced unscheduled DNA synthesis in liver cell cultures from CBA, C57Bl/6j and AKR adult male mice was studied autoradiographically. Ultra-violet radiation (254 nm; 1.5-36 J/m2) triggered on an active unscheduled DNA synthesis in all cell cultures studied. The levels of unscheduled DNA synthesis in the liver cell nuclei of the spontaneous hepatocarcinogenesis-susceptible strain (CBA) and relatively, resistant ones (C57Bl/6j and AKR) were similar. It is suggested that the susceptibility to hepatocarcinogenesis in different murine strains is determined by such parameters as DNA damage and repair (stage of initiation) as well as factors peculiar to the stage of promotion.

Translated title of the contributionDNA reparative synthesis in liver cell cultures from mice with various susceptibilities to spontaneous hepatic carcinogenesis
Original languageRussian
Pages (from-to)73-76
Number of pages4
JournalVoprosy Onkologii
Volume31
Issue number6
StatePublished - Jan 1 1985

ASJC Scopus subject areas

  • Oncology

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