Reparativnyǐ sintez DNK v kul'turakh kletok pecheni mysheǐ s razlicnoǐ predraspolozhennost'iu k spontannomu gepatokantserogenezu.

I. V. Budunova; G. A. Belitskiǐ

Reparativnyǐ sintez DNK v kul'turakh kletok pecheni mysheǐ s razlicnoǐ predraspolozhennost'iu k spontannomu gepatokantserogenezu.

Translated title of the contribution: DNA reparative synthesis in liver cell cultures from mice with various susceptibilities to spontaneous hepatic carcinogenesis

I. V. Budunova^*, G. A. Belitskiǐ

^*Corresponding author for this work

Dermatology

Research output: Contribution to journal › Article › peer-review

Abstract

Ultra-violet radiation-induced unscheduled DNA synthesis in liver cell cultures from CBA, C57Bl/6j and AKR adult male mice was studied autoradiographically. Ultra-violet radiation (254 nm; 1.5-36 J/m2) triggered on an active unscheduled DNA synthesis in all cell cultures studied. The levels of unscheduled DNA synthesis in the liver cell nuclei of the spontaneous hepatocarcinogenesis-susceptible strain (CBA) and relatively, resistant ones (C57Bl/6j and AKR) were similar. It is suggested that the susceptibility to hepatocarcinogenesis in different murine strains is determined by such parameters as DNA damage and repair (stage of initiation) as well as factors peculiar to the stage of promotion.

Translated title of the contribution	DNA reparative synthesis in liver cell cultures from mice with various susceptibilities to spontaneous hepatic carcinogenesis
Original language	Russian
Pages (from-to)	73-76
Number of pages	4
Journal	Voprosy Onkologii
Volume	31
Issue number	6
State	Published - Jan 1 1985

ASJC Scopus subject areas

Oncology

Cite this

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title = "Reparativnyǐ sintez DNK v kul'turakh kletok pecheni mysheǐ s razlicnoǐ predraspolozhennost'iu k spontannomu gepatokantserogenezu.",

abstract = "Ultra-violet radiation-induced unscheduled DNA synthesis in liver cell cultures from CBA, C57Bl/6j and AKR adult male mice was studied autoradiographically. Ultra-violet radiation (254 nm; 1.5-36 J/m2) triggered on an active unscheduled DNA synthesis in all cell cultures studied. The levels of unscheduled DNA synthesis in the liver cell nuclei of the spontaneous hepatocarcinogenesis-susceptible strain (CBA) and relatively, resistant ones (C57Bl/6j and AKR) were similar. It is suggested that the susceptibility to hepatocarcinogenesis in different murine strains is determined by such parameters as DNA damage and repair (stage of initiation) as well as factors peculiar to the stage of promotion.",

author = "Budunova, {I. V.} and Belitskiǐ, {G. A.}",

year = "1985",

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AU - Belitskiǐ, G. A.

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N2 - Ultra-violet radiation-induced unscheduled DNA synthesis in liver cell cultures from CBA, C57Bl/6j and AKR adult male mice was studied autoradiographically. Ultra-violet radiation (254 nm; 1.5-36 J/m2) triggered on an active unscheduled DNA synthesis in all cell cultures studied. The levels of unscheduled DNA synthesis in the liver cell nuclei of the spontaneous hepatocarcinogenesis-susceptible strain (CBA) and relatively, resistant ones (C57Bl/6j and AKR) were similar. It is suggested that the susceptibility to hepatocarcinogenesis in different murine strains is determined by such parameters as DNA damage and repair (stage of initiation) as well as factors peculiar to the stage of promotion.

AB - Ultra-violet radiation-induced unscheduled DNA synthesis in liver cell cultures from CBA, C57Bl/6j and AKR adult male mice was studied autoradiographically. Ultra-violet radiation (254 nm; 1.5-36 J/m2) triggered on an active unscheduled DNA synthesis in all cell cultures studied. The levels of unscheduled DNA synthesis in the liver cell nuclei of the spontaneous hepatocarcinogenesis-susceptible strain (CBA) and relatively, resistant ones (C57Bl/6j and AKR) were similar. It is suggested that the susceptibility to hepatocarcinogenesis in different murine strains is determined by such parameters as DNA damage and repair (stage of initiation) as well as factors peculiar to the stage of promotion.

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Reparativnyǐ sintez DNK v kul'turakh kletok pecheni mysheǐ s razlicnoǐ predraspolozhennost'iu k spontannomu gepatokantserogenezu.

Abstract

ASJC Scopus subject areas

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