TY - JOUR
T1 - Do all components of the metabolic syndrome cluster together in U.S. Hispanics/Latinos? Results from the Hispanic Community Health study/Study of Latinos
AU - Llabre, Maria M.
AU - Arguelles, William
AU - Schneiderman, Neil
AU - Gallo, Linda C.
AU - Daviglus, Martha L.
AU - Chambers, Earle C.
AU - Sotres-Alvarez, Daniela
AU - Chirinos Medina, Diana Andrea
AU - Talavera, Gregory A.
AU - Castaneda, Sheila F.
AU - Roesch, Scott C.
AU - Heiss, Gerardo
N1 - Funding Information:
The authors thank the participants and staff of HCHS/SOL for their important contributions. The study website is http://www.cscc.unc.edu/hchs/ . This work was supported by contracts from the National Heart, Lung, and Blood Institute (NHLBI) to the University of North Carolina ( N01-HC65233 ), University of Miami ( N01-HC65234 ), Albert Einstein College of Medicine ( N01-HC65235 ), Northwestern University ( N01-HC65236 ), and San Diego State University ( N01-HC65237 ). The following institutes, centers, or offices contributed to the baseline HCHS/SOL funding period through a transfer of funds to the NHLBI: National Institute on Minority Health and Health Disparities , National Institute on Deafness and Other Communication Disorders , National Institute of Dental and Craniofacial Research , National Institute of Diabetes and Digestive and Kidney Diseases , National Institute of Neurological Disorders and Stroke , and National Institutes of Health Office of Dietary Supplements. There are no disclosures. M. M. L. had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. M.M.L. also researched the literature, interpreted data, organized and wrote the article, except for the methods. W.A. wrote the methods and critically reviewed, edited, and contributed to the interpretation of data. D.S.-A. reviewed the data analysis, and edited and contributed to the interpretation of the data. N.S., L.C.G., G.A.T., and S.F.C. edited and contributed to the interpretation of the data. M.L.D., E.C.C., D.A.C., S.C.R., and G.H. were involved in manuscript preparation. The contents of this article are solely the responsibility of the authors and do not represent the official position of the National Institutes of Health, the U.S. Department of Health and Human Services, or the federal government. Preliminary data from this study were presented in a symposium at the 71st Scientific Sessions of the American Diabetes Association, San Diego, CA, June 24–28, 2012. No potential conflicts of interest relevant to this article were reported.
Publisher Copyright:
© 2015 Elsevier Inc.
PY - 2015/7/1
Y1 - 2015/7/1
N2 - Purpose: Metabolic syndrome (MetS), the clustering of several risk factors for cardiovascular disease, is highly prevalent in Hispanics/Latinos. We tested whether all components significantly loaded on the syndrome in Hispanics/Latinos and whether their contribution differed by sex and Hispanic ancestry. We also examined associations of MetS with prevalent diabetes and coronary heart disease in Hispanics/Latinos. Methods: Data were obtained from a population-based cohort of n=15,823 participants in the HCHS/SOL study who self-identified as being of Central American, Cuban, Dominican, Mexican American, Puerto Rican, or South American ancestry and were aged 18 to 74years at screening. Results: A latent variable model of waist circumference, systolic and diastolic blood pressure, triglycerides, high-density lipoprotein cholesterol (HDL-C), and fasting glucose fit the data in men and women, but the contribution of HDL-C was weak. No difference in the latent model of MetS was detected across Hispanic/Latino ancestry groups. MetS was significantly associated with diabetes and coronary heart disease. Conclusions: Our results indicate that similar criteria for MetS may be applied across Hispanic/Latino ancestry groups but call into question the role of HDL-C in classifying the MetS in Hispanics/Latinos.
AB - Purpose: Metabolic syndrome (MetS), the clustering of several risk factors for cardiovascular disease, is highly prevalent in Hispanics/Latinos. We tested whether all components significantly loaded on the syndrome in Hispanics/Latinos and whether their contribution differed by sex and Hispanic ancestry. We also examined associations of MetS with prevalent diabetes and coronary heart disease in Hispanics/Latinos. Methods: Data were obtained from a population-based cohort of n=15,823 participants in the HCHS/SOL study who self-identified as being of Central American, Cuban, Dominican, Mexican American, Puerto Rican, or South American ancestry and were aged 18 to 74years at screening. Results: A latent variable model of waist circumference, systolic and diastolic blood pressure, triglycerides, high-density lipoprotein cholesterol (HDL-C), and fasting glucose fit the data in men and women, but the contribution of HDL-C was weak. No difference in the latent model of MetS was detected across Hispanic/Latino ancestry groups. MetS was significantly associated with diabetes and coronary heart disease. Conclusions: Our results indicate that similar criteria for MetS may be applied across Hispanic/Latino ancestry groups but call into question the role of HDL-C in classifying the MetS in Hispanics/Latinos.
KW - Hispanics
KW - Lipids
KW - Metabolic syndrome
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U2 - 10.1016/j.annepidem.2015.02.010
DO - 10.1016/j.annepidem.2015.02.010
M3 - Article
C2 - 25818844
AN - SCOPUS:84930047743
SN - 1047-2797
VL - 25
SP - 480
EP - 485
JO - Annals of Epidemiology
JF - Annals of Epidemiology
IS - 7
ER -
