Do variations in molecular structure affect the clinical efficacy and safety of lipid-based amphotericin B preparations?

Jayesh Mehta*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

38 Scopus citations

Abstract

While amphotericin B is the drug of choice in the treatment of most fungal infections, systemic adverse reactions and dose-dependent nephrotoxicity associated with its use frequently render the conventional preparation of amphotericin unsuitable. A number of lipid-based formulations of amphotericin have been developed to overcome the limitations of the parent compound. These preparations, amphotericin B lipid complex (ABLC), amphotericin B colloid dispersion (ABCD) and liposomal amphotericin differ from one another significantly in their molecular structure. They are also considerably more expensive than the parent compound. Clinical data on their appropriate use are limited. This review looks at the differences in molecular structure of these preparations, and at the available clinical safety and efficacy data.

Original languageEnglish (US)
Pages (from-to)183-188
Number of pages6
JournalLeukemia Research
Volume21
Issue number3
DOIs
StatePublished - Mar 1 1997

Keywords

  • Amphotericin B colloid dispersion
  • Amphotericin B lipid complex
  • Antifungal therapy
  • Fungal infections
  • Liposomal amphotericin
  • Nephrotoxicity

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'Do variations in molecular structure affect the clinical efficacy and safety of lipid-based amphotericin B preparations?'. Together they form a unique fingerprint.

Cite this