Docosahexaenoic and arachidonic acid levels in extremely low birth weight infants with prolonged exposure to intravenous lipids

Daniel T. Robinson*, Susan E. Carlson, Karna Murthy, Brandy Frost, Shengqi Li, Michael Caplan

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

Objective: To report changes in red blood cell long-chain polyunsaturated fatty acids levels in extremely low birth weight (ELBW) infants relative to duration of intravenous lipid emulsion. Study design: Serial blood samples were collected from 26 ELBW infants during the first 2 months of life in the neonatal intensive care unit using a prospective cohort study design. The primary outcome was the change in long-chain polyunsaturated fatty acids levels over the study period relative to a duration of intravenous lipid emulsion of either ≤28 days or >28 days. Secondary outcomes included parenteral and enteral nutritional exposures as well as prematurity-associated morbidities. Longitudinal regression estimated changes in fatty acid levels between the 2 exposure groups. Results: Infants with >28 days intravenous lipid emulsion had 36 more days of intravenous lipid emulsion than did those with ≤28 days (P < .001). Docosahexaenoic acid significantly decreased over time in all infants and decreased significantly more in infants exposed to intravenous lipid emulsion for >28 days (P = .03). Arachidonic acid significantly decreased over the study period but the decrease was not related to intravenous lipid emulsion duration. Linoleic and α-linolenic acids had significantly larger increases over time in those with longer exposure to intravenous lipid emulsion (P < .01). Conclusion: Docosahexaenoic acid status of ELBW infants declined significantly in the first 2 months of life and the decline was significantly greater in those exposed to intravenous lipid emulsion >28 days compared with those exposed ≤28 days.

Original languageEnglish (US)
Pages (from-to)56-61
Number of pages6
JournalJournal of Pediatrics
Volume162
Issue number1
DOIs
StatePublished - Jan 1 2013

Keywords

  • ALA
  • ARA
  • Arachidonic acid
  • BPD
  • Bronchopulmonary dysplasia
  • DHA
  • Docosahexaenoic acid
  • EFA
  • ELBW
  • Essential fatty acids
  • Extremely low birth weight
  • FA
  • FEN
  • Fatty acid
  • Full enteral nutrition
  • LA
  • LCPUFA
  • Linoleic acid
  • Long-chain polyunsaturated fatty acids
  • NDI
  • NEC
  • NICU
  • Necrotizing enterocolitis
  • Neonatal intensive care unit
  • Neurodevelopmental impairment
  • Omega-3
  • RBC
  • Red blood cell
  • n-3
  • α-Linolenic acid

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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