Documentation of Epstein-Barr Virus Infection in Immunodeficient Patients with Life-threatening Lymphoproliferative Diseases by Clinical Virological, and lmmunopathological Studies

David T. Purtilo, Bengt Sandstedt, Nicholas Barnes, Judith Knight, Robert Collins, Jo Ann Cornet, Lauren Pachman, Kenneth Rich, Frank Cruzi, Jon Pincott, Catherine Slooei, Colin Sieff, Lauren Pachman, David T. Purtilo, Ari K. Saemundsen, Ann Christine Synnerholm, Maria Anvret, George Klein, David T. Purtilo, John L. SullivanKiyoshi Sakamoto, David T. Purtilo

Research output: Contribution to journalArticlepeer-review

90 Scopus citations

Abstract

Multiple methods, pedigree analysis, clinical evaluation, and Epstein-Barr virus (EBV)-specific serology, EBV DNA hybridization of tissues to probe for viral genome, staining of touch imprints for EBV nuclear-associated antigen, establishment of spontaneous infected B-cell lines from peripheral blood 01 tissues, examination of peripheral blood smears, and hematopathology studies, were used to study seven patients with the X-linked lymphoproliferative syndrome and seven additional patients with life-threatening EBV-associated diseases. These studies demonstrated EBV in the tissues of all 14 patients and immunodeficient antibody responses to EBV were documented. This virus can produce various life-threatening lymphoproliferative diseases in a variety of immunodeficient patients.

Original languageEnglish (US)
Pages (from-to)4226-4236
Number of pages11
JournalCancer Research
Volume41
StatePublished - Nov 1 1981

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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