Documentation of Epstein-Barr Virus Infection in Immunodeficient Patients with Life-threatening Lymphoproliferative Diseases by Clinical Virological, and lmmunopathological Studies

David T. Purtilo; Bengt Sandstedt; Nicholas Barnes; Judith Knight; Robert Collins; Jo Ann Cornet; Lauren Pachman; Kenneth Rich; Frank Cruzi; Jon Pincott; Catherine Slooei; Colin Sieff; Lauren Pachman; David T. Purtilo; Ari K. Saemundsen; Ann Christine Synnerholm; Maria Anvret; George Klein; David T. Purtilo; John L. Sullivan; Kiyoshi Sakamoto; David T. Purtilo

Documentation of Epstein-Barr Virus Infection in Immunodeficient Patients with Life-threatening Lymphoproliferative Diseases by Clinical Virological, and lmmunopathological Studies

David T. Purtilo, Bengt Sandstedt, Nicholas Barnes, Judith Knight, Robert Collins, Jo Ann Cornet, Lauren Pachman, Kenneth Rich, Frank Cruzi, Jon Pincott, Catherine Slooei, Colin Sieff, Lauren Pachman, David T. Purtilo, Ari K. Saemundsen, Ann Christine Synnerholm, Maria Anvret, George Klein, David T. Purtilo, John L. SullivanKiyoshi Sakamoto, David T. Purtilo

Pediatrics

Research output: Contribution to journal › Article › peer-review

95 Scopus citations

Abstract

Multiple methods, pedigree analysis, clinical evaluation, and Epstein-Barr virus (EBV)-specific serology, EBV DNA hybridization of tissues to probe for viral genome, staining of touch imprints for EBV nuclear-associated antigen, establishment of spontaneous infected B-cell lines from peripheral blood 01 tissues, examination of peripheral blood smears, and hematopathology studies, were used to study seven patients with the X-linked lymphoproliferative syndrome and seven additional patients with life-threatening EBV-associated diseases. These studies demonstrated EBV in the tissues of all 14 patients and immunodeficient antibody responses to EBV were documented. This virus can produce various life-threatening lymphoproliferative diseases in a variety of immunodeficient patients.

Original language	English (US)
Pages (from-to)	4226-4236
Number of pages	11
Journal	Cancer Research
Volume	41
State	Published - Nov 1 1981

ASJC Scopus subject areas

Oncology
Cancer Research

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Purtilo, D. T., Sandstedt, B., Barnes, N., Knight, J., Collins, R., Cornet, J. A., Pachman, L., Rich, K., Cruzi, F., Pincott, J., Slooei, C., Sieff, C., Pachman, L., Purtilo, D. T., Saemundsen, A. K., Synnerholm, A. C., Anvret, M., Klein, G., Purtilo, D. T., ... Purtilo, D. T. (1981). Documentation of Epstein-Barr Virus Infection in Immunodeficient Patients with Life-threatening Lymphoproliferative Diseases by Clinical Virological, and lmmunopathological Studies. Cancer Research, 41, 4226-4236.

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title = "Documentation of Epstein-Barr Virus Infection in Immunodeficient Patients with Life-threatening Lymphoproliferative Diseases by Clinical Virological, and lmmunopathological Studies",

abstract = "Multiple methods, pedigree analysis, clinical evaluation, and Epstein-Barr virus (EBV)-specific serology, EBV DNA hybridization of tissues to probe for viral genome, staining of touch imprints for EBV nuclear-associated antigen, establishment of spontaneous infected B-cell lines from peripheral blood 01 tissues, examination of peripheral blood smears, and hematopathology studies, were used to study seven patients with the X-linked lymphoproliferative syndrome and seven additional patients with life-threatening EBV-associated diseases. These studies demonstrated EBV in the tissues of all 14 patients and immunodeficient antibody responses to EBV were documented. This virus can produce various life-threatening lymphoproliferative diseases in a variety of immunodeficient patients.",

author = "Purtilo, {David T.} and Bengt Sandstedt and Nicholas Barnes and Judith Knight and Robert Collins and Cornet, {Jo Ann} and Lauren Pachman and Kenneth Rich and Frank Cruzi and Jon Pincott and Catherine Slooei and Colin Sieff and Lauren Pachman and Purtilo, {David T.} and Saemundsen, {Ari K.} and Synnerholm, {Ann Christine} and Maria Anvret and George Klein and Purtilo, {David T.} and Sullivan, {John L.} and Kiyoshi Sakamoto and Purtilo, {David T.}",

year = "1981",

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language = "English (US)",

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Purtilo, DT, Sandstedt, B, Barnes, N, Knight, J, Collins, R, Cornet, JA, Pachman, L, Rich, K, Cruzi, F, Pincott, J, Slooei, C, Sieff, C, Pachman, L, Purtilo, DT, Saemundsen, AK, Synnerholm, AC, Anvret, M, Klein, G, Purtilo, DT, Sullivan, JL, Sakamoto, K & Purtilo, DT 1981, 'Documentation of Epstein-Barr Virus Infection in Immunodeficient Patients with Life-threatening Lymphoproliferative Diseases by Clinical Virological, and lmmunopathological Studies', Cancer Research, vol. 41, pp. 4226-4236.

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AU - Purtilo, David T.

AU - Sandstedt, Bengt

AU - Barnes, Nicholas

AU - Knight, Judith

AU - Collins, Robert

AU - Cornet, Jo Ann

AU - Pachman, Lauren

AU - Rich, Kenneth

AU - Cruzi, Frank

AU - Pincott, Jon

AU - Slooei, Catherine

AU - Sieff, Colin

AU - Pachman, Lauren

AU - Purtilo, David T.

AU - Saemundsen, Ari K.

AU - Synnerholm, Ann Christine

AU - Anvret, Maria

AU - Klein, George

AU - Purtilo, David T.

AU - Sullivan, John L.

AU - Sakamoto, Kiyoshi

AU - Purtilo, David T.

PY - 1981/11/1

Y1 - 1981/11/1

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AB - Multiple methods, pedigree analysis, clinical evaluation, and Epstein-Barr virus (EBV)-specific serology, EBV DNA hybridization of tissues to probe for viral genome, staining of touch imprints for EBV nuclear-associated antigen, establishment of spontaneous infected B-cell lines from peripheral blood 01 tissues, examination of peripheral blood smears, and hematopathology studies, were used to study seven patients with the X-linked lymphoproliferative syndrome and seven additional patients with life-threatening EBV-associated diseases. These studies demonstrated EBV in the tissues of all 14 patients and immunodeficient antibody responses to EBV were documented. This virus can produce various life-threatening lymphoproliferative diseases in a variety of immunodeficient patients.

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Documentation of Epstein-Barr Virus Infection in Immunodeficient Patients with Life-threatening Lymphoproliferative Diseases by Clinical Virological, and lmmunopathological Studies

Abstract

ASJC Scopus subject areas

UN SDGs

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