TY - JOUR
T1 - DOES KAWASAKI DISEASE HAVE A RETROVIRAL AETIOLOGY?
AU - Shulman, Stanford T.
AU - Rowley, Anne H.
N1 - Funding Information:
We thank Ms Donna Morrison for technical assistance. Supported by The Children’s Memorial Hospital Kawasaki Research Fund and NIH grant
Copyright:
Copyright 2015 Elsevier B.V., All rights reserved.
PY - 1986/9/6
Y1 - 1986/9/6
N2 - In 18 consecutive children with Kawasaki disease of recent onset, reverse transcriptase (RT) activity was studied in co-cultivated peripheral-blood-mononuclear-cell/lymphoblastoid-cell supernatants. 8 of 18 children, but only 1 of 18 controls, showed RT activity in one or more sample (p = 0.009). RT activity was identified in 14 of 226 samples from patients, but in only 1 of 167 from controls (p < 0.01). The findings suggest that a retroviral agent may be casually related to Kawasaki disease.
AB - In 18 consecutive children with Kawasaki disease of recent onset, reverse transcriptase (RT) activity was studied in co-cultivated peripheral-blood-mononuclear-cell/lymphoblastoid-cell supernatants. 8 of 18 children, but only 1 of 18 controls, showed RT activity in one or more sample (p = 0.009). RT activity was identified in 14 of 226 samples from patients, but in only 1 of 167 from controls (p < 0.01). The findings suggest that a retroviral agent may be casually related to Kawasaki disease.
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U2 - 10.1016/S0140-6736(86)90115-7
DO - 10.1016/S0140-6736(86)90115-7
M3 - Article
C2 - 2427900
AN - SCOPUS:0022455230
SN - 0140-6736
VL - 328
SP - 545
EP - 546
JO - The Lancet
JF - The Lancet
IS - 8506
ER -