Does minimizing neuroleptic dosage influence hyponatremia?

Carla M. Canuso, Morris B. Goldman*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


Neuroleptic dosage was reduced by 10% every 2 weeks in five male hyponatremic polydipsic patients with schizophrenia. Mean dose fell from 1980 ± 1289 to 631 ± 135 chlorpromazine equivalents/day over a mean of 12.2 weeks until behavioral relapse occurred. During this time, serum sodium did not vary from baseline levels (132.9 ± 4.9 mEq/l), suggesting that minimizing neuroleptic dose does not alter the severity of hyponatremia in these patients.

Original languageEnglish (US)
Pages (from-to)227-229
Number of pages3
JournalPsychiatry Research
Issue number2-3
StatePublished - Jul 31 1996


  • Polydipsia
  • Schizophrenia
  • Side effects
  • Water intoxication

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

Fingerprint Dive into the research topics of 'Does minimizing neuroleptic dosage influence hyponatremia?'. Together they form a unique fingerprint.

Cite this