Does PTEN loss impair DNA double-strand break repair by homologous recombination?

Clayton R. Hunt, Arun Gupta, Nobuo Horikoshi, Tej K. Pandita*

*Corresponding author for this work

Research output: Contribution to journalComment/debatepeer-review

22 Scopus citations

Abstract

The tumor suppressor PTEN is frequently lost in cancer cells, resulting in altered radiation and drug sensitivity. However, the role of PTEN in DNA repair is controversial. Detailed studies in prostate cancer cells now indicate PTEN does not regulate RAD51 expression or homologous recombination and is not a biomarker for PARP inhibitor sensitivity.

Original languageEnglish (US)
Pages (from-to)920-922
Number of pages3
JournalClinical Cancer Research
Volume18
Issue number4
DOIs
StatePublished - Feb 15 2012

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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