Domain packing and dynamics in the DNA complex of the N-terminal zinc fingers of TFIIIA

M. P. Foster; D. S. Wuttke; I. Radhakrishnan; D. A. Case; J. M. Gottesfeld; P. E. Wright

doi:10.1038/nsb0897-605

Domain packing and dynamics in the DNA complex of the N-terminal zinc fingers of TFIIIA

M. P. Foster, D. S. Wuttke, I. Radhakrishnan, D. A. Case, J. M. Gottesfeld, P. E. Wright^*

^*Corresponding author for this work

Molecular Biosciences

Research output: Contribution to journal › Article › peer-review

121 Scopus citations

Abstract

The three N-terminal zinc fingers of transcription factor Ilia bind in the DNA major groove. Substantial packing interfaces are formed between adjacent fingers, the linkers lose their intrinsic flexibility upon DNA binding, and several lysine side chains implicated in DNA recognition are dynamically disordered.

Original language	English (US)
Pages (from-to)	605-608
Number of pages	4
Journal	Nature Structural Biology
Volume	4
Issue number	8
DOIs	https://doi.org/10.1038/nsb0897-605
State	Published - 1997

ASJC Scopus subject areas

Structural Biology
Biochemistry
Genetics

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title = "Domain packing and dynamics in the DNA complex of the N-terminal zinc fingers of TFIIIA",

abstract = "The three N-terminal zinc fingers of transcription factor Ilia bind in the DNA major groove. Substantial packing interfaces are formed between adjacent fingers, the linkers lose their intrinsic flexibility upon DNA binding, and several lysine side chains implicated in DNA recognition are dynamically disordered.",

author = "Foster, {M. P.} and Wuttke, {D. S.} and I. Radhakrishnan and Case, {D. A.} and Gottesfeld, {J. M.} and Wright, {P. E.}",

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AU - Foster, M. P.

AU - Wuttke, D. S.

AU - Radhakrishnan, I.

AU - Case, D. A.

AU - Gottesfeld, J. M.

AU - Wright, P. E.

PY - 1997

Y1 - 1997

N2 - The three N-terminal zinc fingers of transcription factor Ilia bind in the DNA major groove. Substantial packing interfaces are formed between adjacent fingers, the linkers lose their intrinsic flexibility upon DNA binding, and several lysine side chains implicated in DNA recognition are dynamically disordered.

AB - The three N-terminal zinc fingers of transcription factor Ilia bind in the DNA major groove. Substantial packing interfaces are formed between adjacent fingers, the linkers lose their intrinsic flexibility upon DNA binding, and several lysine side chains implicated in DNA recognition are dynamically disordered.

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Domain packing and dynamics in the DNA complex of the N-terminal zinc fingers of TFIIIA

Abstract

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