Domain packing and dynamics in the DNA complex of the N-terminal zinc fingers of TFIIIA

M. P. Foster, D. S. Wuttke, I. Radhakrishnan, D. A. Case, J. M. Gottesfeld, P. E. Wright*

*Corresponding author for this work

Research output: Contribution to journalArticle

114 Scopus citations

Abstract

The three N-terminal zinc fingers of transcription factor Ilia bind in the DNA major groove. Substantial packing interfaces are formed between adjacent fingers, the linkers lose their intrinsic flexibility upon DNA binding, and several lysine side chains implicated in DNA recognition are dynamically disordered.

Original languageEnglish (US)
Pages (from-to)605-608
Number of pages4
JournalNature Structural Biology
Volume4
Issue number8
DOIs
StatePublished - Aug 14 1997

ASJC Scopus subject areas

  • Biochemistry
  • Structural Biology
  • Genetics

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