Dominant negative myostatin produces hypertrophy without hyperplasia in muscle

Xiaolei Zhu, Michele Hadhazy, Michelle Wehling, James G. Tidball, Elizabeth M. McNally*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

175 Scopus citations

Abstract

Myostatin, a TGF-β family member, is a negative regulator of muscle growth. Here, we generated transgenic mice that expressed myostatin mutated at its cleavage site under the control of a muscle specific promoter creating a dominant negative myostatin. These mice exhibited a significant (20-35%) increase in muscle mass that resulted from myofiber hypertrophy and not from myofiber hyperplasia. We also evaluated the role of myostatin in muscle degenerative states, such as muscular dystrophy, and found significant downregulation of myostatin. Thus, further inhibition of myostatin may permit increased muscle growth in muscle degenerative disorders. Copyright (C) 2000 Federation of European Biochemical Societies.

Original languageEnglish (US)
Pages (from-to)71-75
Number of pages5
JournalFEBS Letters
Volume474
Issue number1
DOIs
StatePublished - May 26 2000

Keywords

  • Muscle development
  • Muscle regeneration
  • Muscular dystrophy
  • TGF-β

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

Fingerprint Dive into the research topics of 'Dominant negative myostatin produces hypertrophy without hyperplasia in muscle'. Together they form a unique fingerprint.

Cite this