Donor bone marrow transplantation: Chimerism and tolerance

Spiros Delis, Gaetano Ciancio*, George W. Burke, Rolando Garcia-Morales, Joshua Miller

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

27 Scopus citations


Infusion of donor bone marrow (DBM)-derived cells continue to be tested in clinical protocols intended to induce specific immunologic tolerance. Central clonal deletion of donor-specific alloreactive cells associated with mixed chimerism reliably produced long-term graft tolerance. In this setting, depletion of recipient T cells by antilymphocyte antibodies and subsequent repopulation by donor hematopoietic cells after donor bone marrow infusion (DBMI) are prerequisites for tolerance induction. Major advances have been made in animal models and in pilot clinical trials and the key questions with the future perspectives are presented in this article.

Original languageEnglish (US)
Pages (from-to)105-115
Number of pages11
JournalTransplant Immunology
Issue number2
StatePublished - 2004


  • Bone marrow transplant
  • Chimerism
  • Tolerance

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Transplantation


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