Donor peripheral blood stem cell infusions in recipients of living- related liver allografts

Alexandra K. Tsaroucha; Camillo Ricordi; Thomas A. Noto; Norma S. Kenyon; Rolando Garcia-Morales; Jose R. Nery; Joshua Miller; Andreas G. Tzakis

doi:10.1097/00007890-199707270-00032

Donor peripheral blood stem cell infusions in recipients of living- related liver allografts

Alexandra K. Tsaroucha, Camillo Ricordi^*, Thomas A. Noto, Norma S. Kenyon, Rolando Garcia-Morales, Jose R. Nery, Joshua Miller, Andreas G. Tzakis

^*Corresponding author for this work

Surgery, Transplant Surgery Division

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Background. In this pilot study, donor peripheral blood stem cell (DPBSC) infusions were performed in three recipients of living-related liver transplants (LRLT). Methods. DPBSCs were obtained by leukapheresis after mobilization with granulocyte-colony-stimulating factor (Filgrastim). Donor leukapheresis was performed on the 5th postoperative day, and half of the DPBSCs were infused into the recipient on the day of collection. The second half of the pheresed product was cryopreserved for delayed administration. Results. Results from preliminary studies of chimerism in LRLT recipients, at 20 weeks posttransplant, suggested that the levels of donor cells detected in LRLT recipients treated with DPBSC infusions may be higher than those observed for recipients of cadaver donor liver allografts and vertebral body marrow infusions. Conclusions. The results of this pilot study indicate that administration of mobilized DPBSC to recipients of LRLT is a feasible procedure for both donor and recipient.

Original language	English (US)
Pages (from-to)	362-364
Number of pages	3
Journal	Transplantation
Volume	64
Issue number	2
DOIs	https://doi.org/10.1097/00007890-199707270-00032
State	Published - Jul 27 1997

ASJC Scopus subject areas

Transplantation

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title = "Donor peripheral blood stem cell infusions in recipients of living- related liver allografts",

abstract = "Background. In this pilot study, donor peripheral blood stem cell (DPBSC) infusions were performed in three recipients of living-related liver transplants (LRLT). Methods. DPBSCs were obtained by leukapheresis after mobilization with granulocyte-colony-stimulating factor (Filgrastim). Donor leukapheresis was performed on the 5th postoperative day, and half of the DPBSCs were infused into the recipient on the day of collection. The second half of the pheresed product was cryopreserved for delayed administration. Results. Results from preliminary studies of chimerism in LRLT recipients, at 20 weeks posttransplant, suggested that the levels of donor cells detected in LRLT recipients treated with DPBSC infusions may be higher than those observed for recipients of cadaver donor liver allografts and vertebral body marrow infusions. Conclusions. The results of this pilot study indicate that administration of mobilized DPBSC to recipients of LRLT is a feasible procedure for both donor and recipient.",

author = "Tsaroucha, {Alexandra K.} and Camillo Ricordi and Noto, {Thomas A.} and Kenyon, {Norma S.} and Rolando Garcia-Morales and Nery, {Jose R.} and Joshua Miller and Tzakis, {Andreas G.}",

year = "1997",

month = jul,

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doi = "10.1097/00007890-199707270-00032",

language = "English (US)",

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pages = "362--364",

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T1 - Donor peripheral blood stem cell infusions in recipients of living- related liver allografts

AU - Tsaroucha, Alexandra K.

AU - Ricordi, Camillo

AU - Noto, Thomas A.

AU - Kenyon, Norma S.

AU - Garcia-Morales, Rolando

AU - Nery, Jose R.

AU - Miller, Joshua

AU - Tzakis, Andreas G.

PY - 1997/7/27

Y1 - 1997/7/27

N2 - Background. In this pilot study, donor peripheral blood stem cell (DPBSC) infusions were performed in three recipients of living-related liver transplants (LRLT). Methods. DPBSCs were obtained by leukapheresis after mobilization with granulocyte-colony-stimulating factor (Filgrastim). Donor leukapheresis was performed on the 5th postoperative day, and half of the DPBSCs were infused into the recipient on the day of collection. The second half of the pheresed product was cryopreserved for delayed administration. Results. Results from preliminary studies of chimerism in LRLT recipients, at 20 weeks posttransplant, suggested that the levels of donor cells detected in LRLT recipients treated with DPBSC infusions may be higher than those observed for recipients of cadaver donor liver allografts and vertebral body marrow infusions. Conclusions. The results of this pilot study indicate that administration of mobilized DPBSC to recipients of LRLT is a feasible procedure for both donor and recipient.

AB - Background. In this pilot study, donor peripheral blood stem cell (DPBSC) infusions were performed in three recipients of living-related liver transplants (LRLT). Methods. DPBSCs were obtained by leukapheresis after mobilization with granulocyte-colony-stimulating factor (Filgrastim). Donor leukapheresis was performed on the 5th postoperative day, and half of the DPBSCs were infused into the recipient on the day of collection. The second half of the pheresed product was cryopreserved for delayed administration. Results. Results from preliminary studies of chimerism in LRLT recipients, at 20 weeks posttransplant, suggested that the levels of donor cells detected in LRLT recipients treated with DPBSC infusions may be higher than those observed for recipients of cadaver donor liver allografts and vertebral body marrow infusions. Conclusions. The results of this pilot study indicate that administration of mobilized DPBSC to recipients of LRLT is a feasible procedure for both donor and recipient.

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Donor peripheral blood stem cell infusions in recipients of living- related liver allografts

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