Donor predictors of allograft utilization for pediatric heart transplantation

Asma M. Khan, Robert S. Green, Irene D. Lytrivi, Raj Sahulee*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

Pediatric heart transplantations are limited by the supply of donor allografts. We sought to determine the cardiac allograft utilization rate for pediatric donors and identify donor factors that predict graft use for transplantation. The United Network for Organ Sharing deceased donor database was queried from April 30, 2006, to March 31, 2014. Donor risk factors that might affect graft use for cardiac transplantation were evaluated. The pediatric cardiac graft utilization rate was calculated, and logistic regression modeling was performed to determine the relationship of risk factors with graft use for transplantation. During the study period, 6682 eligible cardiac donors <18 years of age were identified, and 3758 (56.2%) grafts were utilized for transplantation. Grafts from male donors (OR 1.181) were significantly associated with graft utilization. Graft donor age >1 year (OR 0.363), non-O blood type (OR 0.586), CDC ‘high-risk’ donor status (OR 0.676), use of inotropes (OR 0.718), use of >2 inotropes (OR 0.328), and donor left ventricular ejection fraction <50% (OR 0.045) were significantly associated with graft nonutilization. The pediatric cardiac allograft utilization rate and risk factors for graft use for transplantation have been identified. Additional studies will be needed to assess the donor–recipient relationship on pediatric transplant outcomes.

Original languageEnglish (US)
Pages (from-to)1269-1275
Number of pages7
JournalTransplant International
Volume29
Issue number12
DOIs
StatePublished - Dec 1 2016

Keywords

  • children
  • donor
  • graft utilization
  • pediatric heart transplantation
  • predictors

ASJC Scopus subject areas

  • Transplantation

Fingerprint Dive into the research topics of 'Donor predictors of allograft utilization for pediatric heart transplantation'. Together they form a unique fingerprint.

Cite this