Donor-specific Antibody Surveillance and Graft Outcomes in Pediatric Kidney Transplant Recipients

Rachel M Engen*, Giulia E. Park, Cooper S. Schumacher, Idoia Gimferrer, Paul Warner, Laura S. Finn, Noel S. Weiss, Jodi M. Smith

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Background: The development of de novo donor-specific antibodies (dnDSA) has been associated with rejection and graft loss in kidney transplantation, and DSA screening is now recommended in all kidney transplant recipients. However, the clinical significance of dnDSA detected by screening patients with a stable creatinine remains unclear. Methods: One hundred three patients younger than 18years receiving a first, kidney alone transplant between December 1, 2007, and December 31, 2013, underwent DSA screening every 3months for 2years posttransplant, with additional testing as clinically indicated. No treatment was given for DSAs in the absence of biopsy-proven rejection. Results: Twenty (19%) patients had dnDSA first detected on a screening test, and 13 (13%) patients had dnDSA first detected on a for-cause test. Mean follow-up time posttransplant was 4.4years. Screening-detected dnDSA was associated with an increased risk of rejection within 3years, microvascular inflammation, and C4d staining on a 2-year protocol biopsy. In a Cox proportional hazards regression, screening-detected dnDSA was not associated with time to 30% decline in estimated glomerular filtration rate (adjusted hazard ratio, 0.88; 95% confidence interval [CI], 0.30-2.00; P=0.598) or graft loss. dnDSA first detected on for-cause testing was associated with a 2.8 times increased risk of decline in graft function (95% CI, 1.08-7.27; P=0.034) and a 7.34 times increased risk of graft loss (95% CI, 1.37-39.23 P=0.020) compared with those who did not develop dnDSA. Conclusions: The clinical setting in which dnDSA is first detected impacts the association between dnDSA and graft function. Further research is needed to clarify the role of dnDSA screening in pediatric kidney transplantation.

Original languageEnglish (US)
Pages (from-to)2072-2079
Number of pages8
JournalTransplantation
Volume102
Issue number12
Early online dateMay 31 2018
DOIs
StatePublished - Dec 1 2018

ASJC Scopus subject areas

  • Transplantation

Fingerprint Dive into the research topics of 'Donor-specific Antibody Surveillance and Graft Outcomes in Pediatric Kidney Transplant Recipients'. Together they form a unique fingerprint.

Cite this