Dopamine agonist treatment of antegrade amnesia from a mediobasal forebrain injury

Bruce H. Dobkin*, Robert Hanlon

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

We studied the persistent antegrade memory impairment in a woman whose brain had been surgically impaled, leaving a 1‐cm‐wide mediobasal tract of encephalomalacia that entended just enterior to the septal, nuclei and medial to the nucleus accumbens. In a blinded, controlled, alternating repeated‐measures protocol, bromocriptine signigicantly improved her verbal learning, functional memory, and dailyrecall, perhaps by acting on neurons that had been disconnected fron the ventral tegmental tract's dopaminergic inputs.

Original languageEnglish (US)
Pages (from-to)313-316
Number of pages4
JournalAnnals of neurology
Volume33
Issue number3
DOIs
StatePublished - Jan 1 1993

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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