Dopamine and synaptic plasticity in dorsal striatal circuits controlling action selection

D. James Surmeier*, Joshua Plotkin, Weixing Shen

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

129 Scopus citations

Abstract

The striatum is thought to play a central role in learning how to choose acts that lead to reward and avoid punishment. Dopamine-dependent modification of striatal synapses in the action selection circuitry has long been thought to be a key step toward this type of learning. The development of new genetic and optical tools has pushed this field forward in the last couple of years, demanding a re-evaluation of models of how experience controls dopamine-dependent synaptic plasticity and how disease states like Parkinson's disease affect the striatal circuitry.

Original languageEnglish (US)
Pages (from-to)621-628
Number of pages8
JournalCurrent opinion in neurobiology
Volume19
Issue number6
DOIs
StatePublished - Dec 2009

ASJC Scopus subject areas

  • Neuroscience(all)

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