Abstract
The striatum is thought to play a central role in learning how to choose acts that lead to reward and avoid punishment. Dopamine-dependent modification of striatal synapses in the action selection circuitry has long been thought to be a key step toward this type of learning. The development of new genetic and optical tools has pushed this field forward in the last couple of years, demanding a re-evaluation of models of how experience controls dopamine-dependent synaptic plasticity and how disease states like Parkinson's disease affect the striatal circuitry.
Original language | English (US) |
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Pages (from-to) | 621-628 |
Number of pages | 8 |
Journal | Current opinion in neurobiology |
Volume | 19 |
Issue number | 6 |
DOIs | |
State | Published - Dec 2009 |
ASJC Scopus subject areas
- Neuroscience(all)