Dopamine antagonism by thioridazine in schizophrenia

H. Y. Meltzer, E. J. Sachar, A. G. Frantz

Research output: Contribution to journalArticlepeer-review

32 Scopus citations


One of the leading current theories of the etiology of schizophrenia is excessive activity of some brain dopaminergic tracts. One of the major objections to the theory is that thioridazine is clinically as effective a treatment for schizophrenia as other neuroleptic drugs, but appears to have fewer dopamine blocking properties than these agents in man and laboratory animals. Serum prolactin levels are increased by dopamine receptor blocking drugs. It was found that thioridazine is as effective as chlorpromazine, trifluperazine, and prolixin enanthate in increasing serum prolactin levels in umedicated schizophrenic patients, indicating that it is an effective dopamine blocking agent.

Original languageEnglish (US)
Pages (from-to)53-57
Number of pages5
JournalBiological psychiatry
Issue number1
StatePublished - Dec 1 1975

ASJC Scopus subject areas

  • Biological Psychiatry


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