@inproceedings{5aff8ce7b34f4bc4b2c3d2bb9707b385,
title = "Dopamine Induced Bistability Enhances Signal Processing in Spiny Neurons",
abstract = "Single unit activity in the striatum of awake monkeys shows a marked dependence on the expected reward that a behavior will elicit. We present a computational model of spiny neurons, the principal neurons of the striatum, to assess the hypothesis that direct neuromodulatory effects of dopamine through the activation of D1 receptors mediate the reward dependency of spiny neuron activity. Dopamine release results in the amplification of key ion currents, leading to the emergence of bistability, which not only modulates the peak firing rate but also introduces a temporal and state dependence of the model's response, thus improving the detectability of temporally correlated inputs.",
author = "Gruber, {Aaron J.} and Solla, {Sara A.} and Houk, {James Charles}",
note = "Publisher Copyright: {\textcopyright} NIPS 2002: Proceedings of the 15th International Conference on Neural Information Processing Systems. All rights reserved.; 15th International Conference on Neural Information Processing Systems, NIPS 2002 ; Conference date: 09-12-2002 Through 14-12-2002",
year = "2002",
language = "English (US)",
series = "NIPS 2002: Proceedings of the 15th International Conference on Neural Information Processing Systems",
publisher = "MIT Press Journals",
pages = "165--172",
editor = "Suzanna Becker and Sebastian Thrun and Klaus Obermayer",
booktitle = "NIPS 2002",
address = "United States",
}