Dopamine neuron glutamate cotransmission evokes a delayed excitation in lateral dorsal striatal cholinergic interneurons

Nao Chuhma*, Susana Mingote, Leora Yetnikoff, Abigail Kalmbach, Thong Ma, Samira Ztaou, Anna Claire Sienna, Sophia Tepler, Jean Francois Poulin, Mark Ansorge, Rajeshwar Awatramani, Un Jung Kang, Stephen Rayport

*Corresponding author for this work

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Dopamine neurons have different synaptic actions in the ventral and dorsal striatum (dStr), but whether this heterogeneity extends to dStr subregions has not been addressed. We have found that optogenetic activation of dStr dopamine neuron terminals in mouse brain slices pauses the firing of cholinergic interneurons in both the medial and lateral subregions, while in the lateral subregion the pause is shorter due to a subsequent excitation. This excitation is mediated mainly by metabotropic glutamate receptor 1 (mGluR1) and partially by dopamine D1-like receptors coupled to transient receptor potential channel 3 and 7. DA neurons do not signal to spiny projection neurons in the medial dStr, while they elicit ionotropic glutamate responses in the lateral dStr. The DA neurons mediating these excitatory signals are in the substantia nigra (SN). Thus, SN dopamine neurons engage different receptors in different postsynaptic neurons in different dStr subregions to convey strikingly different signals. Editorial note: This article has been through an editorial process in which the authors decide how to respond to the issues raised during peer review. The Reviewing Editor’s assessment is that all the issues have been addressed (see decision letter).

Original languageEnglish (US)
Article numbere39786
JournaleLife
Volume7
DOIs
StatePublished - Oct 2018

ASJC Scopus subject areas

  • Neuroscience(all)
  • Immunology and Microbiology(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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    Chuhma, N., Mingote, S., Yetnikoff, L., Kalmbach, A., Ma, T., Ztaou, S., Sienna, A. C., Tepler, S., Poulin, J. F., Ansorge, M., Awatramani, R., Kang, U. J., & Rayport, S. (2018). Dopamine neuron glutamate cotransmission evokes a delayed excitation in lateral dorsal striatal cholinergic interneurons. eLife, 7, [e39786]. https://doi.org/10.7554/eLife.39786