Dopaminergic supersensitivity at distant sites following induced epileptic foci

John G. Csernansky; Cynthia A. Holman; Kenneth A. Bonnet; Kari Grabowsky; Roy King; Leo E. Hollister

doi:10.1016/0024-3205(83)90084-X

Dopaminergic supersensitivity at distant sites following induced epileptic foci

John G. Csernansky^*, Cynthia A. Holman, Kenneth A. Bonnet, Kari Grabowsky, Roy King, Leo E. Hollister

^*Corresponding author for this work

Psychiatry and Behavioral Sciences

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

Injection of ferric chloride (FeCl₃) into the left amygdaloid nucleus of the rat produced partial complex seizures. Subsequent repeated apomorphine challenges revealed steady development of behavioral dopaminergic supersensitivity, above that observed in saline-injected controls. The behavioral supersensitibity observed in FeCl₃-injected animals was accompanied by increases in ³H-spiroperidol binding in contralateral amygdala, striatum and ipsilateral nucleus accumbens. In contrast, saline-injected controls demonstrated bilateral decreases in ³H-spiroperidol binding in amygdala and striatum. The effects of FeCl₃ injection on the behavioral dopaminergic supersensitivity and ³H-spiroperidol binding were eliminated when the anterior commissure was severed.

Original language	English (US)
Pages (from-to)	385-390
Number of pages	6
Journal	Life Sciences
Volume	32
Issue number	4
DOIs	https://doi.org/10.1016/0024-3205(83)90084-X
State	Published - Jan 24 1983

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Pharmacology, Toxicology and Pharmaceutics(all)

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title = "Dopaminergic supersensitivity at distant sites following induced epileptic foci",

abstract = "Injection of ferric chloride (FeCl3) into the left amygdaloid nucleus of the rat produced partial complex seizures. Subsequent repeated apomorphine challenges revealed steady development of behavioral dopaminergic supersensitivity, above that observed in saline-injected controls. The behavioral supersensitibity observed in FeCl3-injected animals was accompanied by increases in 3H-spiroperidol binding in contralateral amygdala, striatum and ipsilateral nucleus accumbens. In contrast, saline-injected controls demonstrated bilateral decreases in 3H-spiroperidol binding in amygdala and striatum. The effects of FeCl3 injection on the behavioral dopaminergic supersensitivity and 3H-spiroperidol binding were eliminated when the anterior commissure was severed.",

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T1 - Dopaminergic supersensitivity at distant sites following induced epileptic foci

AU - Csernansky, John G.

AU - Holman, Cynthia A.

AU - Bonnet, Kenneth A.

AU - Grabowsky, Kari

AU - King, Roy

AU - Hollister, Leo E.

PY - 1983/1/24

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N2 - Injection of ferric chloride (FeCl3) into the left amygdaloid nucleus of the rat produced partial complex seizures. Subsequent repeated apomorphine challenges revealed steady development of behavioral dopaminergic supersensitivity, above that observed in saline-injected controls. The behavioral supersensitibity observed in FeCl3-injected animals was accompanied by increases in 3H-spiroperidol binding in contralateral amygdala, striatum and ipsilateral nucleus accumbens. In contrast, saline-injected controls demonstrated bilateral decreases in 3H-spiroperidol binding in amygdala and striatum. The effects of FeCl3 injection on the behavioral dopaminergic supersensitivity and 3H-spiroperidol binding were eliminated when the anterior commissure was severed.

AB - Injection of ferric chloride (FeCl3) into the left amygdaloid nucleus of the rat produced partial complex seizures. Subsequent repeated apomorphine challenges revealed steady development of behavioral dopaminergic supersensitivity, above that observed in saline-injected controls. The behavioral supersensitibity observed in FeCl3-injected animals was accompanied by increases in 3H-spiroperidol binding in contralateral amygdala, striatum and ipsilateral nucleus accumbens. In contrast, saline-injected controls demonstrated bilateral decreases in 3H-spiroperidol binding in amygdala and striatum. The effects of FeCl3 injection on the behavioral dopaminergic supersensitivity and 3H-spiroperidol binding were eliminated when the anterior commissure was severed.

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Dopaminergic supersensitivity at distant sites following induced epileptic foci

Abstract

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