Dopaminergic supersensitivity at distant sites following induced epileptic foci

John G. Csernansky*, Cynthia A. Holman, Kenneth A. Bonnet, Kari Grabowsky, Roy King, Leo E. Hollister

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

Injection of ferric chloride (FeCl3) into the left amygdaloid nucleus of the rat produced partial complex seizures. Subsequent repeated apomorphine challenges revealed steady development of behavioral dopaminergic supersensitivity, above that observed in saline-injected controls. The behavioral supersensitibity observed in FeCl3-injected animals was accompanied by increases in 3H-spiroperidol binding in contralateral amygdala, striatum and ipsilateral nucleus accumbens. In contrast, saline-injected controls demonstrated bilateral decreases in 3H-spiroperidol binding in amygdala and striatum. The effects of FeCl3 injection on the behavioral dopaminergic supersensitivity and 3H-spiroperidol binding were eliminated when the anterior commissure was severed.

Original languageEnglish (US)
Pages (from-to)385-390
Number of pages6
JournalLife Sciences
Volume32
Issue number4
DOIs
StatePublished - Jan 24 1983

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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