Dopaminergic Transmission Rapidly and Persistently Enhances Excitability of D1 Receptor-Expressing Striatal Projection Neurons

Asha K. Lahiri, Mark D. Bevan*

*Corresponding author for this work

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Lahiri and Bevan demonstrate that dopaminergic transmission powerfully enhances the intrinsic excitability of D1 receptor-expressing striatal projection neurons in a state-independent manner. Dynamic biophysical changes argue that different ion channel mechanisms may underlie the initial and long-lasting phases of modulation.

Original languageEnglish (US)
Pages (from-to)277-290.e6
JournalNeuron
Volume106
Issue number2
DOIs
StatePublished - Apr 22 2020

Keywords

  • Kv1.2
  • afterhyperpolarization
  • basal ganglia
  • direct pathway
  • dorsal striatum
  • gramicidin
  • medium spiny projection neuron
  • neuromodulation
  • optogenetics
  • up state

ASJC Scopus subject areas

  • Neuroscience(all)

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