@article{540505634a664a62837dc7f7ddc1a6a9,
title = "Dopaminergic Transmission Rapidly and Persistently Enhances Excitability of D1 Receptor-Expressing Striatal Projection Neurons",
abstract = "Lahiri and Bevan demonstrate that dopaminergic transmission powerfully enhances the intrinsic excitability of D1 receptor-expressing striatal projection neurons in a state-independent manner. Dynamic biophysical changes argue that different ion channel mechanisms may underlie the initial and long-lasting phases of modulation.",
keywords = "Kv1.2, afterhyperpolarization, basal ganglia, direct pathway, dorsal striatum, gramicidin, medium spiny projection neuron, neuromodulation, optogenetics, up state",
author = "Lahiri, {Asha K.} and Bevan, {Mark D.}",
note = "Funding Information: This study was funded by NIH NINDS grants P50 NS047085 , R37 NS041280 , and F31 NS100357 . Confocal imaging work was performed at the Northwestern University Center for Advanced Microscopy, which is supported by NIH NCI grant CCSG P30 CA060553 (awarded to the Robert H. Lurie Comprehensive Cancer Center). The authors thank C.J. Wilson, J.D. Berke, D.J. Surmeier, Y. Kozorovitskiy, R.J. Miller, and the rest of the Bevan lab for comments on this study. The authors also thank K.M. Wassum and A.L. Collins for training in FSCV, as well as D.J. Surmeier, D.R. Schowalter, and B.M. Erjavec for providing transgenic DAT IRES-Cre and Drd1a-tdTomato breeding mice. Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",
year = "2020",
month = apr,
day = "22",
doi = "10.1016/j.neuron.2020.01.028",
language = "English (US)",
volume = "106",
pages = "277--290.e6",
journal = "Neuron",
issn = "0896-6273",
publisher = "Cell Press",
number = "2",
}