Doppler imaging of intracellular dynamics in clinical cancer chemotherapy

David D. Nolte, John J. Turek, Daniela E. Matei, Shadia Jalal

Research output: Chapter in Book/Report/Conference proceedingConference contribution


Biodynamic imaging of chemotherapy response in ex vivo patient biopsies measures changes of intracellular dynamics in response to applied therapeutics. The technique is based on near-IR low-coherence digital holography of Dopplerbroadened light scattering from intracellular dynamics. Three clinical trials of this diagnostic biophotonic technology are nearing completion in esophageal cancer, epithelial ovarian cancer and breast cancer.

Original languageEnglish (US)
Title of host publicationClinical and Preclinical Optical Diagnostics II
EditorsJ. Quincy Brown, Ton G. van Leeuwen
ISBN (Electronic)9781510628397
StatePublished - 2019
EventClinical and Preclinical Optical Diagnostics II 2019 - Munich, Germany
Duration: Jun 23 2019Jun 25 2019

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


ConferenceClinical and Preclinical Optical Diagnostics II 2019


  • Clinical trial
  • Digital holography
  • Dynamic light Scattering
  • Interferometry
  • Optical coherence tomography

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Biomaterials
  • Radiology Nuclear Medicine and imaging


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