Doppler imaging of intracellular dynamics in clinical cancer chemotherapy

David D. Nolte*, John J. Turek, Daniela E. Matei, Shadia Jalal

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Biodynamic imaging of chemotherapy response in ex vivo patient biopsies measures changes of intracellular dynamics in response to applied therapeutics. The technique is based on near-IR low-coherence digital holography of Doppler-broadened light scattering from intracellular dynamics. Three clinical trials of this diagnostic biophotonic technology are nearing completion in esophageal cancer, epithelial ovarian cancer and breast cancer.

Original languageEnglish (US)
Title of host publicationEuropean Conference on Biomedical Optics, ECBO_2019
PublisherOSA - The Optical Society
ISBN (Electronic)9781557528209
DOIs
StatePublished - Jan 1 2019
EventEuropean Conference on Biomedical Optics, ECBO_2019 - Munich, Netherlands
Duration: Jun 23 2019Jun 25 2019

Publication series

NameOptics InfoBase Conference Papers
VolumePart F142-ECBO 2019

Conference

ConferenceEuropean Conference on Biomedical Optics, ECBO_2019
CountryNetherlands
CityMunich
Period6/23/196/25/19

Keywords

  • Clinical trial
  • Digital holography
  • Dynamic light scattering
  • Interferometry
  • Optical coherence tomography

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Mechanics of Materials

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