@inproceedings{d0a4a3f9bfe94a5eb296b2d5342dee48,
title = "Doppler imaging of intracellular dynamics in clinical cancer chemotherapy",
abstract = "Biodynamic imaging of chemotherapy response in ex vivo patient biopsies measures changes of intracellular dynamics in response to applied therapeutics. The technique is based on near-IR low-coherence digital holography of Dopplerbroadened light scattering from intracellular dynamics. Three clinical trials of this diagnostic biophotonic technology are nearing completion in esophageal cancer, epithelial ovarian cancer and breast cancer.",
keywords = "Clinical trial, Digital holography, Dynamic light Scattering, Interferometry, Optical coherence tomography",
author = "Nolte, {David D.} and Turek, {John J.} and Matei, {Daniela E.} and Shadia Jalal",
note = "Funding Information: Clinical trials of biodynamic imaging in an observational setting are nearing completion with nearly 90 patients tested across 5 combination therapies and three diseases. Prospective trials are beginning, with translation to the clinic to guide chemotherapy selection expected in the near future. This work was supported by NSF CBET-1263753 and NIH NIBIB R01EB016582. Publisher Copyright: {\textcopyright} 2019 SPIE.; Clinical and Preclinical Optical Diagnostics II 2019 ; Conference date: 23-06-2019 Through 25-06-2019",
year = "2019",
doi = "10.1117/12.2527073",
language = "English (US)",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
publisher = "SPIE",
editor = "Brown, {J. Quincy} and {van Leeuwen}, {Ton G.}",
booktitle = "Clinical and Preclinical Optical Diagnostics II",
}
