Doppler left ventricular diastolic filling abnormalities in aortic stenosis and their relation to hemodynamic parameters

Doppler mitral flow indexes and their relation to invasively measured hemodynamic diastolic indexes were assessed in 13 patients with isolated aortic stenosis (AS), and compared to Doppler indexes in 10 normal subjects matched for age, heart rate, left ventricular (LV) ejection fraction and LV load. Patients with AS showed no difference in Doppler early filling (E) indexes, but demonstrated greater Doppler atrial filling (A) indexes in comparison to normal subjects: atrial velocity (89 ± 31 vs 56 ± 7 cm/s), atrial integral (11.4 ± 4.8 vs 5.7 ± 1.6 cm), A/E velocity (1.69 ± 0.89 vs 1.06 ± 0.26) and A/E integral (3.53 ± 6.64 vs 0.81 ± 0.27) (all p <0.05). Doppler indexes in patients with AS did not correlated with hemodynamic indexes of LV relaxation or chamber stiffness. Significant correlations were observed between Doppler and angiographic peak filling rates (r = 0.70) and between Doppler atrial filling velocity and LV end-diastolic volume (r = -0.66), LV end-diastolic pressure (r = -0.48) and LV ejection fraction (r = 0.53) (all p < 0.05). These data indicate that, compared to matched normal subjects, most patients with AS have an increased atrial contribution to LV filling. However, in patients with decreased LV function, atrial function may also be depressed, as indicated by a decreased atrial contribution to LV filling, resulting in "normalization" of the Doppler mitral flow pattern.