Dorsolateral prefrontal contributions to human working memory

Aron K. Barbey*, Michael Koenigs, Jordan Grafman

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

335 Scopus citations

Abstract

Although neuroscience has made remarkable progress in understanding the involvement of prefrontal cortex (PFC) in human memory, the necessity of dorsolateral PFC (dlPFC) for key competencies of working memory remains largely unexplored. We therefore studied human brain lesion patients to determine whether dlPFC is necessary for working memory function, administering subtests of the Wechsler Memory Scale, the Wechsler Adult Intelligence Scale, and the N-Back Task to three participant groups: dlPFC lesions (n = 19), non-dlPFC lesions (n = 152), and no brain lesions (n = 54). DlPFC damage was associated with deficits in the manipulation of verbal and spatial knowledge, with left dlPFC necessary for manipulating information in working memory and right dlPFC critical for manipulating information in a broader range of reasoning contexts. Our findings elucidate the architecture of working memory, providing key neuropsychological evidence for the necessity of dlPFC in the manipulation of verbal and spatial knowledge.

Original languageEnglish (US)
Pages (from-to)1195-1205
Number of pages11
JournalCortex
Volume49
Issue number5
DOIs
StatePublished - May 2013

Keywords

  • Dorsolateral prefrontal cortex
  • Lesion data
  • Prefrontal cortex
  • Working memory

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Experimental and Cognitive Psychology
  • Cognitive Neuroscience

Fingerprint Dive into the research topics of 'Dorsolateral prefrontal contributions to human working memory'. Together they form a unique fingerprint.

Cite this